Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats

Herbert Y. Meltzer; Steven M. Paul; Victor S. Fang

doi:10.1007/BF00431737

Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats

Herbert Y. Meltzer, Steven M. Paul, Victor S. Fang

Washington University School of Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Cis (α)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (β)-flupenthixol and (-)-butaclamol are not. α-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the β-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even greater. These results support the hypothesis that the dopamine receptors that mediate the effects of dopamine on prolactin secretion are similar to those that mediate the anti-psychotic effect of neuroleptic drugs.

Original language	English
Pages (from-to)	181-183
Number of pages	3
Journal	Psychopharmacology
Volume	51
Issue number	2
DOIs	https://doi.org/10.1007/BF00431737
State	Published - Jan 1 1977

Keywords

Butaclamol
Dopamine
Flupenthixol
Prolactin

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10.1007/BF00431737

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abstract = "Cis (α)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (β)-flupenthixol and (-)-butaclamol are not. α-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the β-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even greater. These results support the hypothesis that the dopamine receptors that mediate the effects of dopamine on prolactin secretion are similar to those that mediate the anti-psychotic effect of neuroleptic drugs.",

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AU - Meltzer, Herbert Y.

AU - Paul, Steven M.

AU - Fang, Victor S.

PY - 1977/1/1

Y1 - 1977/1/1

N2 - Cis (α)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (β)-flupenthixol and (-)-butaclamol are not. α-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the β-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even greater. These results support the hypothesis that the dopamine receptors that mediate the effects of dopamine on prolactin secretion are similar to those that mediate the anti-psychotic effect of neuroleptic drugs.

AB - Cis (α)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (β)-flupenthixol and (-)-butaclamol are not. α-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the β-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even greater. These results support the hypothesis that the dopamine receptors that mediate the effects of dopamine on prolactin secretion are similar to those that mediate the anti-psychotic effect of neuroleptic drugs.

KW - Butaclamol

KW - Dopamine

KW - Flupenthixol

KW - Prolactin

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JO - Psychopharmacology

JF - Psychopharmacology

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ER -

Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats

Abstract

Keywords

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