Cis (α)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (β)-flupenthixol and (-)-butaclamol are not. α-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the β-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even greater. These results support the hypothesis that the dopamine receptors that mediate the effects of dopamine on prolactin secretion are similar to those that mediate the anti-psychotic effect of neuroleptic drugs.
|Number of pages||3|
|State||Published - Jan 1 1977|