Effect of exercise training on plasma cholesterol and cholesterol kinetics in adult female rats

Richard E. Ostlund; Mary Reaban

doi:10.1016/0021-9150(89)90201-3

Effect of exercise training on plasma cholesterol and cholesterol kinetics in adult female rats

Richard E. Ostlund, Mary Reaban

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Adult female rats fed laboratory chow of low cholesterol content were trained by swimming for 77 days. Plasma cholesterol concentration decreased 38% compared to sedentary controls. Whole body cholesterol metabolism was studied by injection of [¹⁴C]cholesterol tracer and determination of the plasma cholesterol-specific activity during the last 49 days of the experiment. The rate constant for elemination of cholesterol from the body was 31% higher in swimming than in sedentary animals, and the size of the rapidly-exchanging cholesterol pool was 28% smaller. These results suggest that enhanced cholesterol excretion or catabolism accompanies exercise training in the rat.

Original language	English
Pages (from-to)	7-11
Number of pages	5
Journal	Atherosclerosis
Volume	75
Issue number	1
DOIs	https://doi.org/10.1016/0021-9150(89)90201-3
State	Published - Jan 1989

Keywords

(Rat)
Cholesterol/metabolism
Exertion

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10.1016/0021-9150(89)90201-3

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title = "Effect of exercise training on plasma cholesterol and cholesterol kinetics in adult female rats",

abstract = "Adult female rats fed laboratory chow of low cholesterol content were trained by swimming for 77 days. Plasma cholesterol concentration decreased 38% compared to sedentary controls. Whole body cholesterol metabolism was studied by injection of [14C]cholesterol tracer and determination of the plasma cholesterol-specific activity during the last 49 days of the experiment. The rate constant for elemination of cholesterol from the body was 31% higher in swimming than in sedentary animals, and the size of the rapidly-exchanging cholesterol pool was 28% smaller. These results suggest that enhanced cholesterol excretion or catabolism accompanies exercise training in the rat.",

keywords = "(Rat), Cholesterol/metabolism, Exertion",

author = "Ostlund, {Richard E.} and Mary Reaban",

note = "Funding Information: Supported by NIH grants ROl HL29229 and PO1 AG05562. Correspondence to: Dr. Richard E. Ostlund, Jr., Metabolism Division, Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110. U.S.A.",

year = "1989",

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T1 - Effect of exercise training on plasma cholesterol and cholesterol kinetics in adult female rats

AU - Ostlund, Richard E.

AU - Reaban, Mary

N1 - Funding Information: Supported by NIH grants ROl HL29229 and PO1 AG05562. Correspondence to: Dr. Richard E. Ostlund, Jr., Metabolism Division, Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110. U.S.A.

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N2 - Adult female rats fed laboratory chow of low cholesterol content were trained by swimming for 77 days. Plasma cholesterol concentration decreased 38% compared to sedentary controls. Whole body cholesterol metabolism was studied by injection of [14C]cholesterol tracer and determination of the plasma cholesterol-specific activity during the last 49 days of the experiment. The rate constant for elemination of cholesterol from the body was 31% higher in swimming than in sedentary animals, and the size of the rapidly-exchanging cholesterol pool was 28% smaller. These results suggest that enhanced cholesterol excretion or catabolism accompanies exercise training in the rat.

AB - Adult female rats fed laboratory chow of low cholesterol content were trained by swimming for 77 days. Plasma cholesterol concentration decreased 38% compared to sedentary controls. Whole body cholesterol metabolism was studied by injection of [14C]cholesterol tracer and determination of the plasma cholesterol-specific activity during the last 49 days of the experiment. The rate constant for elemination of cholesterol from the body was 31% higher in swimming than in sedentary animals, and the size of the rapidly-exchanging cholesterol pool was 28% smaller. These results suggest that enhanced cholesterol excretion or catabolism accompanies exercise training in the rat.

KW - (Rat)

KW - Cholesterol/metabolism

KW - Exertion

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JO - Atherosclerosis

JF - Atherosclerosis

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ER -

Effect of exercise training on plasma cholesterol and cholesterol kinetics in adult female rats

Abstract

Keywords

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