@article{06819199009d47a5a9d1badcca2c3e6e,
title = "Effect of excessive gestational weight gain on insulin sensitivity and insulin kinetics in women with overweight/obesity",
abstract = "Objective: Obesity increases the risk for pregnancy complications and maternal hyperglycemia. The Institute of Medicine developed guidelines for gestational weight gain (GWG) targets for women with overweight/obesity, but it is unclear whether exceeding these targets has adverse effects on maternal glucose metabolism. Methods: Insulin sensitivity (assessed using the Matsuda Insulin Sensitivity Index), β-cell function (assessed as insulin secretion rate in relation to plasma glucose), and plasma insulin clearance rate were evaluated using a frequently sampled oral glucose tolerance test at 15 and 35 weeks of gestation in 184 socioeconomically disadvantaged African American women with overweight/obesity. Results: Insulin sensitivity decreased, whereas β-cell function and insulin clearance increased from 15 to 35 weeks of gestation in the entire group. Compared with women who achieved the recommended GWG, excessive GWG was associated with a greater decrease in insulin sensitivity between 15 and 35 weeks. β-cell function and plasma insulin clearance were not affected by excessive GWG. Conclusions: These data demonstrate that gaining more weight during pregnancy than recommended by the Institute of Medicine is associated with functional effects on glucose metabolism.",
author = "Cade, {William Todd} and Bettina Mittendorfer and Patterson, {Bruce W.} and Debra Haire-Joshu and Cahill, {Alison G.} and Stein, {Richard I.} and Schechtman, {Kenneth B.} and Tinius, {Rachel A.} and Katherine Brown and Samuel Klein",
note = "Funding Information: This study was supported by National Institutes of Health (NIH) grants U01 DK094416, P30 DK056341 (Washington University Nutrition and Obesity Research Center), P30 DK092950 (Washington University Center for Diabetes Translation Research), P30 DK20579 (Washington University Diabetes Research Center), and UL1 TR002345 (Washington University Clinical and Translational Science Award) and was part of the Lifestyle Interventions For Expectant Moms (LIFE‐Moms) consortium, which is supported by NIH grants U01 DK094418, U01 DK094463, U01 DK094416, U01 DK094466, U01 HL114344, U01 HL114377, and U01 HD072834, as well as the National Center for Complementary and Integrative Health, the NIH Office of Research in Women's Health, the Office of Behavioral and Social Science Research, the Indian Health Service, and the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases. Publisher Copyright: {\textcopyright} 2022 The Obesity Society.",
year = "2022",
month = oct,
doi = "10.1002/oby.23533",
language = "English",
volume = "30",
pages = "2014--2022",
journal = "Obesity",
issn = "1930-7381",
number = "10",
}