Effect of Estrogen and Estrogen-like Compounds on Atherosclerosis in Cholesterol Fed Cockerels

W. A. Peck, W. D. Woods, Michael Raines, A. M. Dutton, J. L. Orbison

    Research output: Contribution to journalArticle

    2 Scopus citations

    Abstract

    Coronary and aortic atherosclerosis were studied in white leghorn cockerels fed an atherogenic diet and treated with parenteral estradiol benzoate or synthetic estrogen compounds of lower feminizing potency. The estradiol benzoate gave the expected feminization and protection against coronary atherosclerosis and enhanced thoracic aortic atherosclerosis. The 2 iodo-estrone acetate gave some suggested protection to the coronary vasculature, but was not clearly different from the other analogues in this respect. The 2 iodo-estrone enhanced aortic atherosclerosis and was significantly different in this effect from the other analogues. These observations suggest that the effects on atherosclerosis of the coronary arteries and aorta are mediated through molecular configurations different from those mediating feminization.

    Original languageEnglish
    Pages (from-to)786-788
    Number of pages3
    JournalProceedings of the Society for Experimental Biology and Medicine
    Volume108
    Issue number3
    DOIs
    StatePublished - Dec 1961

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