Effect of Estrogen and Estrogen-like Compounds on Atherosclerosis in Cholesterol Fed Cockerels

W. A. Peck; W. D. Woods; Michael Raines; A. M. Dutton; J. L. Orbison

doi:10.3181/00379727-108-27067

Effect of Estrogen and Estrogen-like Compounds on Atherosclerosis in Cholesterol Fed Cockerels

W. A. Peck, W. D. Woods, Michael Raines, A. M. Dutton, J. L. Orbison

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Abstract

Coronary and aortic atherosclerosis were studied in white leghorn cockerels fed an atherogenic diet and treated with parenteral estradiol benzoate or synthetic estrogen compounds of lower feminizing potency. The estradiol benzoate gave the expected feminization and protection against coronary atherosclerosis and enhanced thoracic aortic atherosclerosis. The 2 iodo-estrone acetate gave some suggested protection to the coronary vasculature, but was not clearly different from the other analogues in this respect. The 2 iodo-estrone enhanced aortic atherosclerosis and was significantly different in this effect from the other analogues. These observations suggest that the effects on atherosclerosis of the coronary arteries and aorta are mediated through molecular configurations different from those mediating feminization.

Original language	English
Pages (from-to)	786-788
Number of pages	3
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	108
Issue number	3
DOIs	https://doi.org/10.3181/00379727-108-27067
State	Published - Dec 1961

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abstract = "Coronary and aortic atherosclerosis were studied in white leghorn cockerels fed an atherogenic diet and treated with parenteral estradiol benzoate or synthetic estrogen compounds of lower feminizing potency. The estradiol benzoate gave the expected feminization and protection against coronary atherosclerosis and enhanced thoracic aortic atherosclerosis. The 2 iodo-estrone acetate gave some suggested protection to the coronary vasculature, but was not clearly different from the other analogues in this respect. The 2 iodo-estrone enhanced aortic atherosclerosis and was significantly different in this effect from the other analogues. These observations suggest that the effects on atherosclerosis of the coronary arteries and aorta are mediated through molecular configurations different from those mediating feminization.",

author = "Peck, {W. A.} and Woods, {W. D.} and Michael Raines and Dutton, {A. M.} and Orbison, {J. L.}",

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AU - Peck, W. A.

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AU - Dutton, A. M.

AU - Orbison, J. L.

PY - 1961/12

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N2 - Coronary and aortic atherosclerosis were studied in white leghorn cockerels fed an atherogenic diet and treated with parenteral estradiol benzoate or synthetic estrogen compounds of lower feminizing potency. The estradiol benzoate gave the expected feminization and protection against coronary atherosclerosis and enhanced thoracic aortic atherosclerosis. The 2 iodo-estrone acetate gave some suggested protection to the coronary vasculature, but was not clearly different from the other analogues in this respect. The 2 iodo-estrone enhanced aortic atherosclerosis and was significantly different in this effect from the other analogues. These observations suggest that the effects on atherosclerosis of the coronary arteries and aorta are mediated through molecular configurations different from those mediating feminization.

AB - Coronary and aortic atherosclerosis were studied in white leghorn cockerels fed an atherogenic diet and treated with parenteral estradiol benzoate or synthetic estrogen compounds of lower feminizing potency. The estradiol benzoate gave the expected feminization and protection against coronary atherosclerosis and enhanced thoracic aortic atherosclerosis. The 2 iodo-estrone acetate gave some suggested protection to the coronary vasculature, but was not clearly different from the other analogues in this respect. The 2 iodo-estrone enhanced aortic atherosclerosis and was significantly different in this effect from the other analogues. These observations suggest that the effects on atherosclerosis of the coronary arteries and aorta are mediated through molecular configurations different from those mediating feminization.

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Effect of Estrogen and Estrogen-like Compounds on Atherosclerosis in Cholesterol Fed Cockerels

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