TY - JOUR
T1 - Effect of endurance training on glycerol kinetics during strenuous exercise in humans
AU - Klein, Samuel
AU - Weber, Jean Michel
AU - Coyle, Edward F.
AU - Wolfe, Robert R.
N1 - Funding Information:
From the Department of Internal Medicine, Washington University School of Medicine, St Louis, MO; Departments of,Anesthesiology, and Surgery, The University of Texas Medical Branch and Shriners Burns Institute, Galveston, TX," and the Human Performance Laboratory, Department of IOnesiology and Health Education, The University of Texas at Austin, `Austin, TX. Submitted May 2, 1995; accepted.August 22, 1995. Supported by National Institutes of Health Grants No. DK 49989, DK46017, and Grant No. 15849from the Shriners Hospitals. `Address reprint requests to Samuel Klein, MD, Washington University School of Medicine, 660 S Euclid,Ave, Box 8127, St Louis, MO 63110-1093. Copyright © 1996 by W.B. Saunders Company 0026-0495/96/4503-0013503. 00/0
PY - 1996
Y1 - 1996
N2 - Glycerol kinetics were evaluated during high-intensity exercise in five untrained and five endurance-trained subjects. Glycerol rate of appearance (Ra) in plasma was determined by infusing [2H5]glycerol during rest and 60 minutes of cycle ergometer exercise performed at 70% V̇O2 peak. Mean plasma glycerol concentration was greater in trained than untrained subjects throughout exercise (P < .05). The average glycerol Ra during exercise and the integrated lipolytic response to exercise, expressed as total glycerol Ra above baseline, were both greater in trained (7.85 ± 0.72 μmol · kg-1 · min-1 and 289 ± 50 μmol · kg-1 · h-1, respectively) than in untrained (5.68 ± 0.90 μmol · kg-1 · min-1, and 198 ± 31 μmol · kg-1 · h-1, respectively) subjects (P < .05). We conclude that whole- body lipolytic rates are greater in endurance-trained athletes than in sedentary controls during high-intensity exercise performed st the same relative intensity.
AB - Glycerol kinetics were evaluated during high-intensity exercise in five untrained and five endurance-trained subjects. Glycerol rate of appearance (Ra) in plasma was determined by infusing [2H5]glycerol during rest and 60 minutes of cycle ergometer exercise performed at 70% V̇O2 peak. Mean plasma glycerol concentration was greater in trained than untrained subjects throughout exercise (P < .05). The average glycerol Ra during exercise and the integrated lipolytic response to exercise, expressed as total glycerol Ra above baseline, were both greater in trained (7.85 ± 0.72 μmol · kg-1 · min-1 and 289 ± 50 μmol · kg-1 · h-1, respectively) than in untrained (5.68 ± 0.90 μmol · kg-1 · min-1, and 198 ± 31 μmol · kg-1 · h-1, respectively) subjects (P < .05). We conclude that whole- body lipolytic rates are greater in endurance-trained athletes than in sedentary controls during high-intensity exercise performed st the same relative intensity.
UR - http://www.scopus.com/inward/record.url?scp=0029986156&partnerID=8YFLogxK
U2 - 10.1016/S0026-0495(96)90291-7
DO - 10.1016/S0026-0495(96)90291-7
M3 - Article
C2 - 8606644
AN - SCOPUS:0029986156
VL - 45
SP - 357
EP - 361
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 3
ER -