Effect of contrast medium on amino acid transport in the brain

E. G. Archer, S. D. Herman, F. R. Fortier, E. J. Potchen, B. A. Siegel

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effect of intravenously administered sodium aceirizoaie on mouse brain uptake of glycine and glycine derivatives was studied. The uptake of glycine, which normally is actively transported into brain, was not altered by contrast medium. However, more lipid soluble derivatives of glycine penetrated brain to a greater extent after this mild, insult to the blood-brain barrier. Our results suggest that die use of amino acid analogs labeled with gamma-emitting radionuclides may be useful for the noninvasive investigation of minimal blood-brain barrier dysfunction.

Original languageEnglish
Pages (from-to)382-389
Number of pages8
JournalInvestigative Radiology
Volume7
Issue number5
DOIs
StatePublished - Jan 1 1972

Keywords

  • Amino acids
  • Blood-brain barrier
  • Contrast media
  • Passive permeability

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