TY - JOUR
T1 - Effect of comorbid anxiety on treatment response and relapse risk in late-life depression
T2 - Controlled study
AU - Andreescu, Carmen
AU - Lenze, Eric J.
AU - Dew, Mary Amanda
AU - Begley, Amy E.
AU - Mulsant, Benoit H.
AU - Dombrovski, Alexandre Y.
AU - Pollock, Bruce G.
AU - Stack, Jacqueline
AU - Miller, Mark D.
AU - Reynolds, Charles F.
PY - 2007/4
Y1 - 2007/4
N2 - Background: Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment. Aims: To examine whether anxiety symptoms predict acute and maintenance (2 years) treatment response in late-life depression. Method: Data were drawn from a randomised double-blind study of pharmacotherapy and interpersonal psychotherapy for patients age 70 years and over with major depression. Anxiety symptoms were measured using the Brief Symptom Inventory. Survival analysis tested the effect of pre-treatment anxiety on response and recurrence. Results: Patients with greater pre-treatment anxiety took longer to respond to treatment and had higher rates of recurrence. Actuarial recurrence rates were 29% (pharmacotherapy, lower anxiety), 58% (pharmacotherapy, higher anxiety), 54% (placebo, lower anxiety) and 81% (placebo, higher anxiety). Conclusions: Improved identification and management of anxiety in late-life depression are needed to achieve response and stabilise recovery.
AB - Background: Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment. Aims: To examine whether anxiety symptoms predict acute and maintenance (2 years) treatment response in late-life depression. Method: Data were drawn from a randomised double-blind study of pharmacotherapy and interpersonal psychotherapy for patients age 70 years and over with major depression. Anxiety symptoms were measured using the Brief Symptom Inventory. Survival analysis tested the effect of pre-treatment anxiety on response and recurrence. Results: Patients with greater pre-treatment anxiety took longer to respond to treatment and had higher rates of recurrence. Actuarial recurrence rates were 29% (pharmacotherapy, lower anxiety), 58% (pharmacotherapy, higher anxiety), 54% (placebo, lower anxiety) and 81% (placebo, higher anxiety). Conclusions: Improved identification and management of anxiety in late-life depression are needed to achieve response and stabilise recovery.
UR - http://www.scopus.com/inward/record.url?scp=34147205286&partnerID=8YFLogxK
U2 - 10.1192/bjp.bp.106.027169
DO - 10.1192/bjp.bp.106.027169
M3 - Article
C2 - 17401042
AN - SCOPUS:34147205286
SN - 0007-1250
VL - 190
SP - 344
EP - 349
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - APR.
ER -