EFFECT OF CARBON DIOXIDE IN ACUTE MOUNTAIN SICKNESS: A REDISCOVERY

T. C. Harvey; M. H. Winterborn; N. A. Lassen; M. E. Raichle; J. Jensen; N. V. Richardson; A. R. Bradwell

doi:10.1016/S0140-6736(88)90465-5

EFFECT OF CARBON DIOXIDE IN ACUTE MOUNTAIN SICKNESS: A REDISCOVERY

T. C. Harvey
, M. H. Winterborn
, N. A. Lassen
, M. E. Raichle
, J. Jensen
, N. V. Richardson
, A. R. Bradwell

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The effect of adding CO₂ to inhaled air in six subjects with acute mountain sickness was investigated during a medical expedition to 5400 m. 3% CO₂ in ambient air increased ventilation and resulted in a rise in PaO₂ of between 24% and 40%. There was a 9-28% increase in PaCO₂ and a reduction of the respiratory alkalosis normally seen at high altitude. Symptoms of acute mountain sickness were rapidly relieved. In three subjects cerebral blood flow increased by 17-39%, so that oxygen delivery to the brain would have been considerably improved. This study confirms earlier suggestions of the beneficial effect of CO₂ inhalation at high altitude.

Original language	English
Pages (from-to)	639-641
Number of pages	3
Journal	The Lancet
Volume	332
Issue number	8612
DOIs	https://doi.org/10.1016/S0140-6736(88)90465-5
State	Published - Sep 17 1988

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@article{e770734a0fb440b3b0f32079fe823b0a,

title = "EFFECT OF CARBON DIOXIDE IN ACUTE MOUNTAIN SICKNESS: A REDISCOVERY",

abstract = "The effect of adding CO2 to inhaled air in six subjects with acute mountain sickness was investigated during a medical expedition to 5400 m. 3\% CO2 in ambient air increased ventilation and resulted in a rise in PaO2 of between 24\% and 40\%. There was a 9-28\% increase in PaCO2 and a reduction of the respiratory alkalosis normally seen at high altitude. Symptoms of acute mountain sickness were rapidly relieved. In three subjects cerebral blood flow increased by 17-39\%, so that oxygen delivery to the brain would have been considerably improved. This study confirms earlier suggestions of the beneficial effect of CO2 inhalation at high altitude.",

author = "Harvey, \{T. C.\} and Winterborn, \{M. H.\} and Lassen, \{N. A.\} and Raichle, \{M. E.\} and J. Jensen and Richardson, \{N. V.\} and Bradwell, \{A. R.\}",

note = "Funding Information: This work was made possible by the help and enthusiasm of the members of the B.M.R.E.S. We are grateful to Dr R. A. Stockley for help and advice. Material and fmancial support was provided by Amersham International, the Arthur Thompson Trust (Birmingham University), Kontron Ltd, Radiometer Ltd (Copenhagen), the Wellcome Foundation, the West Midlands Regional Health Authority, Wyeth Pharmaceuticals, and many others who contributed to the expedition.",

year = "1988",

month = sep,

day = "17",

doi = "10.1016/S0140-6736(88)90465-5",

language = "English",

volume = "332",

pages = "639--641",

journal = "The Lancet",

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T1 - EFFECT OF CARBON DIOXIDE IN ACUTE MOUNTAIN SICKNESS

T2 - A REDISCOVERY

AU - Harvey, T. C.

AU - Winterborn, M. H.

AU - Lassen, N. A.

AU - Raichle, M. E.

AU - Jensen, J.

AU - Richardson, N. V.

AU - Bradwell, A. R.

N1 - Funding Information: This work was made possible by the help and enthusiasm of the members of the B.M.R.E.S. We are grateful to Dr R. A. Stockley for help and advice. Material and fmancial support was provided by Amersham International, the Arthur Thompson Trust (Birmingham University), Kontron Ltd, Radiometer Ltd (Copenhagen), the Wellcome Foundation, the West Midlands Regional Health Authority, Wyeth Pharmaceuticals, and many others who contributed to the expedition.

PY - 1988/9/17

Y1 - 1988/9/17

N2 - The effect of adding CO2 to inhaled air in six subjects with acute mountain sickness was investigated during a medical expedition to 5400 m. 3% CO2 in ambient air increased ventilation and resulted in a rise in PaO2 of between 24% and 40%. There was a 9-28% increase in PaCO2 and a reduction of the respiratory alkalosis normally seen at high altitude. Symptoms of acute mountain sickness were rapidly relieved. In three subjects cerebral blood flow increased by 17-39%, so that oxygen delivery to the brain would have been considerably improved. This study confirms earlier suggestions of the beneficial effect of CO2 inhalation at high altitude.

AB - The effect of adding CO2 to inhaled air in six subjects with acute mountain sickness was investigated during a medical expedition to 5400 m. 3% CO2 in ambient air increased ventilation and resulted in a rise in PaO2 of between 24% and 40%. There was a 9-28% increase in PaCO2 and a reduction of the respiratory alkalosis normally seen at high altitude. Symptoms of acute mountain sickness were rapidly relieved. In three subjects cerebral blood flow increased by 17-39%, so that oxygen delivery to the brain would have been considerably improved. This study confirms earlier suggestions of the beneficial effect of CO2 inhalation at high altitude.

UR - https://www.scopus.com/pages/publications/0023724552

U2 - 10.1016/S0140-6736(88)90465-5

DO - 10.1016/S0140-6736(88)90465-5

M3 - Article

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AN - SCOPUS:0023724552

SN - 0140-6736

VL - 332

SP - 639

EP - 641

JO - The Lancet

JF - The Lancet

IS - 8612

ER -

EFFECT OF CARBON DIOXIDE IN ACUTE MOUNTAIN SICKNESS: A REDISCOVERY

Abstract

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