@article{e770734a0fb440b3b0f32079fe823b0a,
title = "EFFECT OF CARBON DIOXIDE IN ACUTE MOUNTAIN SICKNESS: A REDISCOVERY",
abstract = "The effect of adding CO2 to inhaled air in six subjects with acute mountain sickness was investigated during a medical expedition to 5400 m. 3% CO2 in ambient air increased ventilation and resulted in a rise in PaO2 of between 24% and 40%. There was a 9-28% increase in PaCO2 and a reduction of the respiratory alkalosis normally seen at high altitude. Symptoms of acute mountain sickness were rapidly relieved. In three subjects cerebral blood flow increased by 17-39%, so that oxygen delivery to the brain would have been considerably improved. This study confirms earlier suggestions of the beneficial effect of CO2 inhalation at high altitude.",
author = "Harvey, {T. C.} and Winterborn, {M. H.} and Lassen, {N. A.} and Raichle, {M. E.} and J. Jensen and Richardson, {N. V.} and Bradwell, {A. R.}",
note = "Funding Information: This work was made possible by the help and enthusiasm of the members of the B.M.R.E.S. We are grateful to Dr R. A. Stockley for help and advice. Material and fmancial support was provided by Amersham International, the Arthur Thompson Trust (Birmingham University), Kontron Ltd, Radiometer Ltd (Copenhagen), the Wellcome Foundation, the West Midlands Regional Health Authority, Wyeth Pharmaceuticals, and many others who contributed to the expedition.",
year = "1988",
month = sep,
day = "17",
doi = "10.1016/S0140-6736(88)90465-5",
language = "English",
volume = "332",
pages = "639--641",
journal = "The Lancet",
issn = "0140-6736",
number = "8612",
}