TY - JOUR
T1 - Effect of calorie restriction on the free-living physical activity levels of nonobese humans
T2 - Results of three randomized trials
AU - Martin, Corby K.
AU - Das, Sai Krupa
AU - Lindblad, Lauren
AU - Racette, Susan B.
AU - McCrory, Megan A.
AU - Weiss, Edward P.
AU - DeLany, James P.
AU - Kraus, William E.
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Effect of calorie restriction on the free-living physical activity levels of nonobese humans: Results of three randomized trials. J Appl Physiol 110: 956-963, 2011. First published February 3, 2011; doi:10.1152/japplphysiol.00846. 2009.- The objective of this study was to evaluate the influence of calorie restriction (CR) on free-living physical activity levels among humans. Data were from three CALERIE phase I site-specific protocols. Participants were nonobese (body mass index = 23.5-29.9 kg/m2) adults randomly assigned to 25% CR, low-calorie diet (LCD, 890 kcal/day supplement diet until 15% weight loss, then weight maintenance), or control at Pennington Biomedical Research Center (PBRC); 30% or 10% CR at Tufts University; and 20% CR or control at Washington University School of Medicine (WUSM). Activity was measured at months 0, 3, and 6 (PBRC) and at months 0, 3, 6, 9, and 12 (WUSM and Tufts). Total daily energy expenditure (TEE) by doubly labeled water and resting metabolic rate (RMR) were used to compute activity energy expenditure: AEE = TEE - RMR - 0.1 = TEE. Accelerometry and 7-day recall categorized activities by intensity. At Tufts, the 10% and 30% CR groups experienced significant decreases in AEE at months 6, 9, and 12. At month 6, a larger decrease in AEE was observed in the CR than the control group at WUSM. At months 3 and 6, larger decreases in AEE were observed in the CR and LCD groups than the control group at PBRC. Accelerometry and 7-day PAR did not consistently detect changes in activity categories. CR-associated changes in AEE were variable but, generally, reduced the energy deficit, which would reduce the expected rate of weight loss. Accelerometry and recall did not consistently explain reduced AEE, suggesting that increased muscle efficiency and/or decreased fidgeting accounted for decreased AEE. Inaccuracy of accelerometry and recall also likely negatively affected sensitivity.
AB - Effect of calorie restriction on the free-living physical activity levels of nonobese humans: Results of three randomized trials. J Appl Physiol 110: 956-963, 2011. First published February 3, 2011; doi:10.1152/japplphysiol.00846. 2009.- The objective of this study was to evaluate the influence of calorie restriction (CR) on free-living physical activity levels among humans. Data were from three CALERIE phase I site-specific protocols. Participants were nonobese (body mass index = 23.5-29.9 kg/m2) adults randomly assigned to 25% CR, low-calorie diet (LCD, 890 kcal/day supplement diet until 15% weight loss, then weight maintenance), or control at Pennington Biomedical Research Center (PBRC); 30% or 10% CR at Tufts University; and 20% CR or control at Washington University School of Medicine (WUSM). Activity was measured at months 0, 3, and 6 (PBRC) and at months 0, 3, 6, 9, and 12 (WUSM and Tufts). Total daily energy expenditure (TEE) by doubly labeled water and resting metabolic rate (RMR) were used to compute activity energy expenditure: AEE = TEE - RMR - 0.1 = TEE. Accelerometry and 7-day recall categorized activities by intensity. At Tufts, the 10% and 30% CR groups experienced significant decreases in AEE at months 6, 9, and 12. At month 6, a larger decrease in AEE was observed in the CR than the control group at WUSM. At months 3 and 6, larger decreases in AEE were observed in the CR and LCD groups than the control group at PBRC. Accelerometry and 7-day PAR did not consistently detect changes in activity categories. CR-associated changes in AEE were variable but, generally, reduced the energy deficit, which would reduce the expected rate of weight loss. Accelerometry and recall did not consistently explain reduced AEE, suggesting that increased muscle efficiency and/or decreased fidgeting accounted for decreased AEE. Inaccuracy of accelerometry and recall also likely negatively affected sensitivity.
KW - Accelerometry
KW - Activity energy expenditure
KW - Exercise
UR - http://www.scopus.com/inward/record.url?scp=79954589262&partnerID=8YFLogxK
U2 - 10.1152/japplphysiol.00846.2009
DO - 10.1152/japplphysiol.00846.2009
M3 - Article
C2 - 21292847
AN - SCOPUS:79954589262
SN - 8750-7587
VL - 110
SP - 956
EP - 963
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 4
ER -