TY - JOUR
T1 - Effect of calcium therapy in the sick premature infant with early neonatal hypocalcemia
AU - Scott, Susan M.
AU - Ladenson, Jack H.
AU - Aguanna, James J.
AU - Walgate, Jean
AU - Hillman, Laura S.
N1 - Funding Information:
Front the Departments of Pediatrics and Pathology, Washington University School of Medicine, the Division of Neonatology, St. Louis Children's ltospital, attd the Division of Bone and Mineral Metabolism, Jewish llospital of St. Louis. Supported by grants from the National Institutes of tlealth (5T32AM07033 \[S.M.S.\], HD-09998 \[L.S.tLl , and ES-07066-03 IJ.J.A.\] ). Reprint requests: Susan M. Scott. M.D., A-17, Harbor-UCLA Medical Center, 1000 W. Carson St., Torrt~nce, CA 90509.
PY - 1984/5
Y1 - 1984/5
N2 - Twenty-seven sick premature infants with serum calcium concentrations <6.0 mg/dl during the first day of age were enrolled in a prospective controlled study involving two treatment regimens-calcium given as a bolus or a drip-or no treatment. Mean total calcium concentration was 5.5±0.8 mg/dl, and ionized calcium was 3.1±.3 mg/dl, with no significant difference between treatment groups. By 24 hours, in all groups total calcium had increased to >6.0 mg/dl (bolus 6.5±1.1, drip 7.0±0.4, control 6.6±0.4) and ionized calcium to >3.5 mg/dl (bolus 3.9±0.3, drip 3.6±0.6, control 3.6±0.3). Ionized and total calcium concentrations were significantly correlated (r=0.562; P<0.001), but total calcium did not predict ionized calcium in any group. These data support the concept that, even in sick infants, early neonatal hypocalcemia is a physiologic phenomenon that may not require treatment.
AB - Twenty-seven sick premature infants with serum calcium concentrations <6.0 mg/dl during the first day of age were enrolled in a prospective controlled study involving two treatment regimens-calcium given as a bolus or a drip-or no treatment. Mean total calcium concentration was 5.5±0.8 mg/dl, and ionized calcium was 3.1±.3 mg/dl, with no significant difference between treatment groups. By 24 hours, in all groups total calcium had increased to >6.0 mg/dl (bolus 6.5±1.1, drip 7.0±0.4, control 6.6±0.4) and ionized calcium to >3.5 mg/dl (bolus 3.9±0.3, drip 3.6±0.6, control 3.6±0.3). Ionized and total calcium concentrations were significantly correlated (r=0.562; P<0.001), but total calcium did not predict ionized calcium in any group. These data support the concept that, even in sick infants, early neonatal hypocalcemia is a physiologic phenomenon that may not require treatment.
UR - http://www.scopus.com/inward/record.url?scp=0021267909&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(84)80960-9
DO - 10.1016/S0022-3476(84)80960-9
M3 - Article
C2 - 6716222
AN - SCOPUS:0021267909
VL - 104
SP - 747
EP - 751
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 5
ER -