TY - JOUR
T1 - Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital
AU - Hoffman, Paula L.
AU - Tabakoff, Boris
AU - Szabo, Gyula
AU - Suzdak, Peter D.
AU - Paul, Steven M.
N1 - Funding Information:
The authors thank Ms. Frances Moses for excellent technical assistance. Ro15-4513 was generously provided by Dr. W.E. Haefely (F. Hoffmann-LaRoche and Co., Basel, Switzerland). Ro15-1788 was also supplied by F. Hoffmann-LaRoche and Co., and CGS-8216 was provided by CIBA-Geigy. This work was supported in part by the Banbury Foundation. G.Sz. is a Fogarty International Research Associate and P.D.S. is a Pharmacology Research Associate of NIGMS.
PY - 1987/8/3
Y1 - 1987/8/3
N2 - The imidazobenzodiazepine, Ro15-4513, which is a partial inverse agonist at brain benzodiazepine receptors, reversed the incoordinating effect of ethanol in mice, as measured on an accelerating Rotarod. This effect was blocked by benzodiazepine receptor antagonists. In contrast, Ro15-4513 had no effect on ethanol-induced hypothermia in mice. However, Ro15-4513 reversed the hypothermic effect of pentobarbital, and, at a higher dose, also reversed the incoordinating effect of pentobarbital in mice. The data support the hypothesis that certain of the pharmacological effects of ethanol are mediated by actions at the GABA-benzodiazepine receptor-coupled chloride channel.
AB - The imidazobenzodiazepine, Ro15-4513, which is a partial inverse agonist at brain benzodiazepine receptors, reversed the incoordinating effect of ethanol in mice, as measured on an accelerating Rotarod. This effect was blocked by benzodiazepine receptor antagonists. In contrast, Ro15-4513 had no effect on ethanol-induced hypothermia in mice. However, Ro15-4513 reversed the hypothermic effect of pentobarbital, and, at a higher dose, also reversed the incoordinating effect of pentobarbital in mice. The data support the hypothesis that certain of the pharmacological effects of ethanol are mediated by actions at the GABA-benzodiazepine receptor-coupled chloride channel.
UR - http://www.scopus.com/inward/record.url?scp=0023220764&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(87)90415-2
DO - 10.1016/0024-3205(87)90415-2
M3 - Article
C2 - 3600196
AN - SCOPUS:0023220764
SN - 0024-3205
VL - 41
SP - 611
EP - 620
JO - Life Sciences
JF - Life Sciences
IS - 5
ER -