Effect of 12 months of intense exercise training on stroke volume in patients with coronary artery disease

J. M. Hagberg; A. A. Ehsani; J. O. Holloszy

doi:10.1161/01.CIR.67.6.1194

Effect of 12 months of intense exercise training on stroke volume in patients with coronary artery disease

J. M. Hagberg, A. A. Ehsani, J. O. Holloszy

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Abstract

The purpose of this study was to determine whether 12 months of intense endurance exercise training can induce an increase in left ventricular volume and in stroke work during exercise in patients with coronary artery disease. Eleven male patients were studied. With training, mean maximal oxygen uptake capacity (V̇O₂max) increased 39%, from 1.85 ± 0.36 to 2.57 ± 0.43 l/min. Stroke volume during upright exercise that required 35-65% of V̇O₂max was 18% higher after training. At the same percentage of V̇O₂max, mean blood pressure was the same before and after training; as a result, left ventricular stroke work (mean blood pressure x stroke volume) increased 18% (p <0.01). These findings suggest that in patients with coronary artery disease, prolonged, intense training induces an increase in stroke volume, and this is a result of cardiac rather than peripheral adaptations.

Original language	English
Pages (from-to)	1194-1199
Number of pages	6
Journal	Circulation
Volume	67
Issue number	6 I
DOIs	https://doi.org/10.1161/01.CIR.67.6.1194
State	Published - Jan 1 1983

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Hagberg, J. M., Ehsani, A. A., & Holloszy, J. O. (1983). Effect of 12 months of intense exercise training on stroke volume in patients with coronary artery disease. Circulation, 67(6 I), 1194-1199. https://doi.org/10.1161/01.CIR.67.6.1194

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abstract = "The purpose of this study was to determine whether 12 months of intense endurance exercise training can induce an increase in left ventricular volume and in stroke work during exercise in patients with coronary artery disease. Eleven male patients were studied. With training, mean maximal oxygen uptake capacity ({\.V}O2max) increased 39%, from 1.85 ± 0.36 to 2.57 ± 0.43 l/min. Stroke volume during upright exercise that required 35-65% of {\.V}O2max was 18% higher after training. At the same percentage of {\.V}O2max, mean blood pressure was the same before and after training; as a result, left ventricular stroke work (mean blood pressure x stroke volume) increased 18% (p <0.01). These findings suggest that in patients with coronary artery disease, prolonged, intense training induces an increase in stroke volume, and this is a result of cardiac rather than peripheral adaptations.",

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