Abstract
Aim: To determine whether the TKTL1 protein epitope detection in monocytes (EDIM) test allows detection of upregulated glucose metabolism in malignancies. Materials & methods: The EDIM-TKTL1 blood test was conducted in 240 patients with 17 different confirmed or suspected malignancies. Test scores were compared with 18F-fluoro-2-deoxy-D-glucose (FDG)-PET/computed tomography (CT) results. Results: EDIM-TKTL1 score and FDG-PET results showed a concordance of 90% with a sensitivity of 94% and specificity of 81%. Including CT data, all values were enhanced. A subgroup analysis of non-small-cell lung cancer patients showed a significant correlation between the EDIM-TKTL1 score and the primary tumor size determined by FDG-PET/CT. Conclusion: EDIM-TKTL1 blood test revealed good concordance with FDG-PET/CT results in patients with malignancies demonstrating its efficacy to detect upregulation of glucose metabolism in primary tumors or metastases.
| Original language | English |
|---|---|
| Pages (from-to) | 1349-1359 |
| Number of pages | 11 |
| Journal | Future Oncology |
| Volume | 8 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2012 |
Keywords
- EDIM
- FDG-PET
- TKTL1
- blood test
- diagnostic
- glucose metabolism
- malignancy
- oncology
- transketolase-like-1
- upregulation
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