EDIM-TKTL1 blood test: A noninvasive method to detect upregulated glucose metabolism in patients with malignancies

Oliver Feyen; Johannes F. Coy; Vikas Prasad; Ralf Schierl; Joerg Saenger; Richard P. Baum

doi:10.2217/fon.12.98

EDIM-TKTL1 blood test: A noninvasive method to detect upregulated glucose metabolism in patients with malignancies

Oliver Feyen, Johannes F. Coy, Vikas Prasad, Ralf Schierl, Joerg Saenger, Richard P. Baum

Division of Nuclear Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Aim: To determine whether the TKTL1 protein epitope detection in monocytes (EDIM) test allows detection of upregulated glucose metabolism in malignancies. Materials & methods: The EDIM-TKTL1 blood test was conducted in 240 patients with 17 different confirmed or suspected malignancies. Test scores were compared with ¹⁸F-fluoro-2-deoxy-D-glucose (FDG)-PET/computed tomography (CT) results. Results: EDIM-TKTL1 score and FDG-PET results showed a concordance of 90% with a sensitivity of 94% and specificity of 81%. Including CT data, all values were enhanced. A subgroup analysis of non-small-cell lung cancer patients showed a significant correlation between the EDIM-TKTL1 score and the primary tumor size determined by FDG-PET/CT. Conclusion: EDIM-TKTL1 blood test revealed good concordance with FDG-PET/CT results in patients with malignancies demonstrating its efficacy to detect upregulation of glucose metabolism in primary tumors or metastases.

Original language	English
Pages (from-to)	1349-1359
Number of pages	11
Journal	Future Oncology
Volume	8
Issue number	10
DOIs	https://doi.org/10.2217/fon.12.98
State	Published - Oct 2012

Keywords

EDIM
FDG-PET
TKTL1
blood test
diagnostic
glucose metabolism
malignancy
oncology
transketolase-like-1
upregulation

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title = "EDIM-TKTL1 blood test: A noninvasive method to detect upregulated glucose metabolism in patients with malignancies",

abstract = "Aim: To determine whether the TKTL1 protein epitope detection in monocytes (EDIM) test allows detection of upregulated glucose metabolism in malignancies. Materials & methods: The EDIM-TKTL1 blood test was conducted in 240 patients with 17 different confirmed or suspected malignancies. Test scores were compared with 18F-fluoro-2-deoxy-D-glucose (FDG)-PET/computed tomography (CT) results. Results: EDIM-TKTL1 score and FDG-PET results showed a concordance of 90% with a sensitivity of 94% and specificity of 81%. Including CT data, all values were enhanced. A subgroup analysis of non-small-cell lung cancer patients showed a significant correlation between the EDIM-TKTL1 score and the primary tumor size determined by FDG-PET/CT. Conclusion: EDIM-TKTL1 blood test revealed good concordance with FDG-PET/CT results in patients with malignancies demonstrating its efficacy to detect upregulation of glucose metabolism in primary tumors or metastases.",

keywords = "EDIM, FDG-PET, TKTL1, blood test, diagnostic, glucose metabolism, malignancy, oncology, transketolase-like-1, upregulation",

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year = "2012",

month = oct,

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pages = "1349--1359",

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AU - Feyen, Oliver

AU - Coy, Johannes F.

AU - Prasad, Vikas

AU - Schierl, Ralf

AU - Saenger, Joerg

AU - Baum, Richard P.

PY - 2012/10

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N2 - Aim: To determine whether the TKTL1 protein epitope detection in monocytes (EDIM) test allows detection of upregulated glucose metabolism in malignancies. Materials & methods: The EDIM-TKTL1 blood test was conducted in 240 patients with 17 different confirmed or suspected malignancies. Test scores were compared with 18F-fluoro-2-deoxy-D-glucose (FDG)-PET/computed tomography (CT) results. Results: EDIM-TKTL1 score and FDG-PET results showed a concordance of 90% with a sensitivity of 94% and specificity of 81%. Including CT data, all values were enhanced. A subgroup analysis of non-small-cell lung cancer patients showed a significant correlation between the EDIM-TKTL1 score and the primary tumor size determined by FDG-PET/CT. Conclusion: EDIM-TKTL1 blood test revealed good concordance with FDG-PET/CT results in patients with malignancies demonstrating its efficacy to detect upregulation of glucose metabolism in primary tumors or metastases.

AB - Aim: To determine whether the TKTL1 protein epitope detection in monocytes (EDIM) test allows detection of upregulated glucose metabolism in malignancies. Materials & methods: The EDIM-TKTL1 blood test was conducted in 240 patients with 17 different confirmed or suspected malignancies. Test scores were compared with 18F-fluoro-2-deoxy-D-glucose (FDG)-PET/computed tomography (CT) results. Results: EDIM-TKTL1 score and FDG-PET results showed a concordance of 90% with a sensitivity of 94% and specificity of 81%. Including CT data, all values were enhanced. A subgroup analysis of non-small-cell lung cancer patients showed a significant correlation between the EDIM-TKTL1 score and the primary tumor size determined by FDG-PET/CT. Conclusion: EDIM-TKTL1 blood test revealed good concordance with FDG-PET/CT results in patients with malignancies demonstrating its efficacy to detect upregulation of glucose metabolism in primary tumors or metastases.

KW - EDIM

KW - FDG-PET

KW - TKTL1

KW - blood test

KW - diagnostic

KW - glucose metabolism

KW - malignancy

KW - oncology

KW - transketolase-like-1

KW - upregulation

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ER -

EDIM-TKTL1 blood test: A noninvasive method to detect upregulated glucose metabolism in patients with malignancies

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