ECT and TRH: Cholinergic involvement in a cognitive deficit state

A. Khan, M. H. Mirolo, H. Lai, K. Claypoole, L. Bierut, R. Malik, J. Bhang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In this paper we describe the findings from two preliminary experiments, a human and an animal study, investigating whether thyrotropin-releasing hormone (TRH) can mitigate electroconvulsive therapy (ECT)-induced cognitive deficits. Our results suggest further explorations of TRH and its analogs as possible therapeutic agents for these deficits. We speculate that the major cause of the ECT-induced cognitive deficits is a decrease in cholinergic transmission in the central nervous system. Treatments such as TRH, which enhance cholinergic activity, can reverse the cognitive deficits.

Original languageEnglish
Pages (from-to)345-352
Number of pages8
JournalPsychopharmacology Bulletin
Volume29
Issue number3
StatePublished - Dec 20 1993

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