ECT and TRH: Cholinergic involvement in a cognitive deficit state

A. Khan; M. H. Mirolo; H. Lai; K. Claypoole; L. Bierut; R. Malik; J. Bhang

ECT and TRH: Cholinergic involvement in a cognitive deficit state

A. Khan, M. H. Mirolo, H. Lai, K. Claypoole, L. Bierut, R. Malik, J. Bhang

Research output: Contribution to journal › Article › peer-review

Abstract

In this paper we describe the findings from two preliminary experiments, a human and an animal study, investigating whether thyrotropin-releasing hormone (TRH) can mitigate electroconvulsive therapy (ECT)-induced cognitive deficits. Our results suggest further explorations of TRH and its analogs as possible therapeutic agents for these deficits. We speculate that the major cause of the ECT-induced cognitive deficits is a decrease in cholinergic transmission in the central nervous system. Treatments such as TRH, which enhance cholinergic activity, can reverse the cognitive deficits.

Original language	English
Pages (from-to)	345-352
Number of pages	8
Journal	Psychopharmacology Bulletin
Volume	29
Issue number	3
State	Published - Dec 20 1993

Cite this

@article{d9d623c1e9e04cbea109e9aad4a7996e,

title = "ECT and TRH: Cholinergic involvement in a cognitive deficit state",

abstract = "In this paper we describe the findings from two preliminary experiments, a human and an animal study, investigating whether thyrotropin-releasing hormone (TRH) can mitigate electroconvulsive therapy (ECT)-induced cognitive deficits. Our results suggest further explorations of TRH and its analogs as possible therapeutic agents for these deficits. We speculate that the major cause of the ECT-induced cognitive deficits is a decrease in cholinergic transmission in the central nervous system. Treatments such as TRH, which enhance cholinergic activity, can reverse the cognitive deficits.",

author = "A. Khan and Mirolo, {M. H.} and H. Lai and K. Claypoole and L. Bierut and R. Malik and J. Bhang",

year = "1993",

month = dec,

day = "20",

language = "English",

volume = "29",

pages = "345--352",

journal = "Psychopharmacology Bulletin",

issn = "0048-5764",

number = "3",

}

TY - JOUR

T1 - ECT and TRH

T2 - Cholinergic involvement in a cognitive deficit state

AU - Khan, A.

AU - Mirolo, M. H.

AU - Lai, H.

AU - Claypoole, K.

AU - Bierut, L.

AU - Malik, R.

AU - Bhang, J.

PY - 1993/12/20

Y1 - 1993/12/20

N2 - In this paper we describe the findings from two preliminary experiments, a human and an animal study, investigating whether thyrotropin-releasing hormone (TRH) can mitigate electroconvulsive therapy (ECT)-induced cognitive deficits. Our results suggest further explorations of TRH and its analogs as possible therapeutic agents for these deficits. We speculate that the major cause of the ECT-induced cognitive deficits is a decrease in cholinergic transmission in the central nervous system. Treatments such as TRH, which enhance cholinergic activity, can reverse the cognitive deficits.

AB - In this paper we describe the findings from two preliminary experiments, a human and an animal study, investigating whether thyrotropin-releasing hormone (TRH) can mitigate electroconvulsive therapy (ECT)-induced cognitive deficits. Our results suggest further explorations of TRH and its analogs as possible therapeutic agents for these deficits. We speculate that the major cause of the ECT-induced cognitive deficits is a decrease in cholinergic transmission in the central nervous system. Treatments such as TRH, which enhance cholinergic activity, can reverse the cognitive deficits.

UR - http://www.scopus.com/inward/record.url?scp=0027140288&partnerID=8YFLogxK

M3 - Article

C2 - 8121962

AN - SCOPUS:0027140288

SN - 0048-5764

VL - 29

SP - 345

EP - 352

JO - Psychopharmacology Bulletin

JF - Psychopharmacology Bulletin

IS - 3

ER -

ECT and TRH: Cholinergic involvement in a cognitive deficit state

Abstract

Other files and links

Fingerprint

Cite this