Ecological and evolutionary forces shaping microbial diversity in the human intestine

Ruth E. Ley, Daniel A. Peterson, Jeffrey I. Gordon

Research output: Contribution to journalReview article

1820 Scopus citations

Abstract

The human gut is populated with as many as 100 trillion cells, whose collective genome, the microbiome, is a reflection of evolutionary selection pressures acting at the level of the host and at the level of the microbial cell. The ecological rules that govern the shape of microbial diversity in the gut apply to mutualists and pathogens alike.

Original languageEnglish
Pages (from-to)837-848
Number of pages12
JournalCell
Volume124
Issue number4
DOIs
StatePublished - Feb 24 2006

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