Echocardiographic Tissue Characterization Demonstrates Differences in the Left and Right Sides of the Ventricular Septum

Mark R. Holland, Allyson A. Gibson, Adam Q. Bauer, Linda R. Peterson, Jean E. Schaffer, Richard G. Bach, Sharon Cresci, James G. Miller

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The left and right ventricular function of the heart are influenced by the complex structure of the ventricular septum. The cyclic variation of ultrasonic backscatter over the cardiac cycle is known to be sensitive to both structural and functional characteristics of the myocardium. The objective of this study was to investigate differences in the measured magnitude and normalized delay of cyclic variation between the left and right sides of the ventricular septum in normal adult subjects (N = 31). The measured mean magnitudes of cyclic variation were found to be 4.9 ± 0.4 dB and 2.4 ± 0.3 dB (mean ± SE; p < 0.0001) and the corresponding normalized delay values were found to be 0.94 ± 0.05 and 1.59 ± 0.12 (mean ± SE; p < 0.0001) for the left and right sides, respectively. These results show significant differences in the measured magnitude and normalized delay of cyclic variation between the left and right sides of the ventricular septum in normal subjects that appear consistent with predictions based on previously described models of cyclic variation of backscatter and reported measurements of transmural differences in strain properties of the septum. (E-mail: mrh@wuphys.wustl.edu).

Original languageEnglish
Pages (from-to)1653-1661
Number of pages9
JournalUltrasound in Medicine and Biology
Volume36
Issue number10
DOIs
StatePublished - Oct 1 2010

Keywords

  • Cyclic variation of backscatter
  • Myocardium
  • Ventricular septum

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