TY - JOUR
T1 - Echocardiographic characterization of fundamental mechanisms of abnormal diastolic filling in diabetic rats with a parameterized diastolic filling formalism
AU - Dent, Catherine L.
AU - Bowman, Andrew W.
AU - Scott, Michael J.
AU - Allen, John S.
AU - Lisauskas, Jennifer B.
AU - Janif, Mohammed
AU - Wickline, Samuel A.
AU - Kovács, Sándor J.
N1 - Funding Information:
Supported by grants HL 42950 (S.A.W.), HL 54179, HL 04023 (S.J.K.) (Bethesda, Md), Alan A. and Edith L. Wolf Charitable Trust (St. Louis, Mo), Missouri Affiliate of the American Heart Association (St. Louis, Mo), and Whitaker Foundation (Roslyn, Va).
PY - 2001
Y1 - 2001
N2 - Abnormalities of diastolic function (DF) precede systolic dysfunction in diabetic cardiomyopathy. Transmitral Doppler flow analysis is the primary method for noninvasively assessing DF. We used model-based Doppler E-wave analysis to evaluate diastolic function differences between normal and diabetic rat hearts. Control rats and those with diabetes underwent echocardiography with analysis by traditional Doppler indexes and by the parameterized diastolic filling (PDF) formalism, generating 3 parameters, x0, c, and k, that uniquely characterize each E-wave. Significant intergroup differences in the E/A ratios (P < .01), isovolumic relaxation times (P < .01), and the modeling parameter c (P < .05) were found. There were no significant differences in shortening fraction, deceleration time, myocardial collagen content, or the parameters x0 and k between diabetic and control rats. These results indicate that differences in diastolic function may be noninvasively quantified and that diabetic hearts may exhibit defects in uncoupling of the contractile apparatus without concomitant increases in chamber stiffness.
AB - Abnormalities of diastolic function (DF) precede systolic dysfunction in diabetic cardiomyopathy. Transmitral Doppler flow analysis is the primary method for noninvasively assessing DF. We used model-based Doppler E-wave analysis to evaluate diastolic function differences between normal and diabetic rat hearts. Control rats and those with diabetes underwent echocardiography with analysis by traditional Doppler indexes and by the parameterized diastolic filling (PDF) formalism, generating 3 parameters, x0, c, and k, that uniquely characterize each E-wave. Significant intergroup differences in the E/A ratios (P < .01), isovolumic relaxation times (P < .01), and the modeling parameter c (P < .05) were found. There were no significant differences in shortening fraction, deceleration time, myocardial collagen content, or the parameters x0 and k between diabetic and control rats. These results indicate that differences in diastolic function may be noninvasively quantified and that diabetic hearts may exhibit defects in uncoupling of the contractile apparatus without concomitant increases in chamber stiffness.
UR - http://www.scopus.com/inward/record.url?scp=0035209426&partnerID=8YFLogxK
U2 - 10.1067/mje.2001.115124
DO - 10.1067/mje.2001.115124
M3 - Article
C2 - 11734783
AN - SCOPUS:0035209426
VL - 14
SP - 1166
EP - 1172
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
SN - 0894-7317
IS - 12
ER -