Eccrine angiomatous hamartoma: A clinicopathologic review of 18 cases

Andrew T. Patterson, Monique G. Kumar, Susan J. Bayliss, Patricia M. Witman, Louis P. Dehner, Alejandro A. Gru

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10 Scopus citations


Background: Eccrine angiomatous hamartoma (EAH) is a benign cutaneous lesion defined by the proliferation of hamartomatous eccrine and capillary-like vascular elements in the dermis. However, the epidemiologic, morphologic, and histopathologic aspects of this uncommon disorder have yet to be fully delineated. Methods: The authors retrospectively reviewed 18 EAH cases (including 14 accompanying skin biopsy specimens) diagnosed at 4 American university hospitals from 1996 to 2014. Results: Patients ranged from 3 days to 84 years at time of diagnosis with a median age of 15 years. A male:female ratio of 11:7 was observed. Sixty-seven percent of cases presented in the extremities, but lesions in the trunk and head/neck regions also occurred. Four patients had multiple lesions, and 2 displayed a segmental pattern. Histologically, dermal vascular dilatation and acanthosis often accompanied EAH's typical eccrine and vascular comingling. One individual developed EAH at the site of a recurrent squamous cell carcinoma after previous excision. Conclusions: Although previously thought to occur primarily as a solitary angiomatous-appearing malformation on the extremities of children, EAH may develop with some frequency in adults and may manifest in a multifocal linear distribution. The authors also raise additional histopathologic consideration in support of the vascular theory of histogenesis for this condition.

Original languageEnglish
Pages (from-to)413-417
Number of pages5
JournalAmerican Journal of Dermatopathology
Issue number6
StatePublished - Jun 1 2016


  • capillary
  • eccrine angiomatous hamartoma
  • eccrine proliferation
  • hamartoma
  • squamous cell carcinoma
  • trauma
  • vascular tumor

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