Ebolavirus VP35 is a multifunctional virulence factor

Daisy W. Leung, Kathleen C. Prins, Christopher F. Basler, Gaya K. Amarasinghe

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic fever during sporadic outbreaks, and no approved treatments are currently available. The multifunctional EBOV VP35 protein facilitates immune evasion by antagonizing antiviral signaling pathways and is important for viral RNA synthesis. In order to elucidate regulatory mechanisms and to develop countermeasures, we recently solved the structures of the Zaire and Reston EBOV VP35 interferon inhibitory domain (IID) in the free form and of the Zaire EBOV VP35 IID bound to dsRNA. Together with biochemical, cell biological and virological studies, our structural work revealed that distinct regions within EBOV VP35 IID contribute to virulence through host immune evasion and viral RNA synthesis. Here we summarize our recent structural and functional studies and discuss the potential of multifunctional Ebola VP35 as a therapeutic target.

Original languageEnglish
Pages (from-to)526-531
Number of pages6
JournalVirulence
Volume1
Issue number6
DOIs
StatePublished - Jul 2010

Keywords

  • Drug target
  • Ebola virus
  • Filoviruses
  • IFN antagonist
  • Immune evasion
  • Marburg virus
  • RNA binding protein
  • VP35
  • Virulence factor

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