TY - JOUR
T1 - Early versus delayed correction of infantile strabismus in macaque monkeys
T2 - Effects on horizontal binocular connections in the striate cortex
AU - Richards, Michael
AU - Tychsen, Lawrence
AU - Burkhalter, Andreas
AU - Foeller, Paul
AU - Bradley, Dolores
AU - Wong, Agnes M.F.
N1 - Funding Information:
This work was supported by Grant EY10214 (LT) from the NIH, A Walt and Lilly Disney Award for Amblyopia Research from Research to Prevent Blindness (LT), Grant MOP 67104 (AW) and a New Investigator Award (AW) from the Canadian Institutes of Health Research. Presented at the 16th International Neuro-Ophthalmology Society Meeting, Tokyo, Japan. November 29–December 1, 2006. Address correspondence to Agnes Wong, Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8. E-mail: [email protected]
PY - 2007/9
Y1 - 2007/9
N2 - Objective: To determine how the duration of infantile strabismus influences the development of horizontal connections in V1. Methods: Six infant macaques were fitted with prisms, which were removed after 3 weeks (wks.), 3 months (mos.), or 6 mos. Two control monkeys wore plano lenses. The number of horizontal connections was determined using neuroanatomic techniques. Results: The 3-wks animal had equal number of monocular (51%) and binocular (49%) connections. In the 6-mos. animal, however, monocular connections (76%) were three times more abundant than binocular (24%) connections (p < 0.001). Conclusions: Longer duration of infantile strabismus causes greater deficit of binocular connections. Early correction of infantile strabismus is supported.
AB - Objective: To determine how the duration of infantile strabismus influences the development of horizontal connections in V1. Methods: Six infant macaques were fitted with prisms, which were removed after 3 weeks (wks.), 3 months (mos.), or 6 mos. Two control monkeys wore plano lenses. The number of horizontal connections was determined using neuroanatomic techniques. Results: The 3-wks animal had equal number of monocular (51%) and binocular (49%) connections. In the 6-mos. animal, however, monocular connections (76%) were three times more abundant than binocular (24%) connections (p < 0.001). Conclusions: Longer duration of infantile strabismus causes greater deficit of binocular connections. Early correction of infantile strabismus is supported.
KW - Binocular connections
KW - Infantile strabismus
KW - Ocular dominance columns
KW - Primary visual cortex
KW - V1
UR - http://www.scopus.com/inward/record.url?scp=36249002393&partnerID=8YFLogxK
U2 - 10.1080/01658100701647720
DO - 10.1080/01658100701647720
M3 - Article
AN - SCOPUS:36249002393
SN - 0165-8107
VL - 31
SP - 171
EP - 174
JO - Neuro-Ophthalmology
JF - Neuro-Ophthalmology
IS - 5-6
ER -