Early versus delayed correction of infantile strabismus in macaque monkeys: Effects on horizontal binocular connections in the striate cortex

Michael Richards, Lawrence Tychsen, Andreas Burkhalter, Paul Foeller, Dolores Bradley, Agnes M.F. Wong

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective: To determine how the duration of infantile strabismus influences the development of horizontal connections in V1. Methods: Six infant macaques were fitted with prisms, which were removed after 3 weeks (wks.), 3 months (mos.), or 6 mos. Two control monkeys wore plano lenses. The number of horizontal connections was determined using neuroanatomic techniques. Results: The 3-wks animal had equal number of monocular (51%) and binocular (49%) connections. In the 6-mos. animal, however, monocular connections (76%) were three times more abundant than binocular (24%) connections (p < 0.001). Conclusions: Longer duration of infantile strabismus causes greater deficit of binocular connections. Early correction of infantile strabismus is supported.

Original languageEnglish
Pages (from-to)171-174
Number of pages4
JournalNeuro-Ophthalmology
Volume31
Issue number5-6
DOIs
StatePublished - Sep 2007

Keywords

  • Binocular connections
  • Infantile strabismus
  • Ocular dominance columns
  • Primary visual cortex
  • V1

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