TY - JOUR
T1 - Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F β-amyloid precursor protein
AU - Dodart, Jean Cosme
AU - Mathis, Chantal
AU - Bales, Kelly R.
AU - Paul, Steven M.
AU - Ungerer, Arielle
N1 - Funding Information:
This work was supported by Eli Lilly Research Labatories (Indianapolis, USA) and by a grant of the Association France Alzheimer (Paris, France).
PY - 1999/12/17
Y1 - 1999/12/17
N2 - In the present study, we examined whether the relative levels of regional brain [14C]2-deoxyglucose (2-DG) uptake are altered in a transgenic mouse model of Alzheimer's disease which overexpresses a mutated form of the human β-amyloid precursor protein (mutation V717F). We show that the relative levels of 2-DG uptake are significantly reduced in the septum, thalamus, dentate gyrus and parietal cortex of 3-month-old transgenic mice as compared with wild-type littermates. In 10-month-old transgenic mice, these alterations also extend to the CA3 hippocampal region, the cingulate, retrosplenial, occipital and temporal cortices, suggesting an age-dependent decrease in the regional 2-DG uptake. These results suggest that expression of a mutated APP gene induces an early regional cerebral hypometabolism independently of amyloid deposition per se. Copyright (C) 1999 Elsevier Science Ireland Ltd.
AB - In the present study, we examined whether the relative levels of regional brain [14C]2-deoxyglucose (2-DG) uptake are altered in a transgenic mouse model of Alzheimer's disease which overexpresses a mutated form of the human β-amyloid precursor protein (mutation V717F). We show that the relative levels of 2-DG uptake are significantly reduced in the septum, thalamus, dentate gyrus and parietal cortex of 3-month-old transgenic mice as compared with wild-type littermates. In 10-month-old transgenic mice, these alterations also extend to the CA3 hippocampal region, the cingulate, retrosplenial, occipital and temporal cortices, suggesting an age-dependent decrease in the regional 2-DG uptake. These results suggest that expression of a mutated APP gene induces an early regional cerebral hypometabolism independently of amyloid deposition per se. Copyright (C) 1999 Elsevier Science Ireland Ltd.
KW - Alzheimer's disease
KW - Brain glucose metabolism
KW - Transgenic mice
KW - [C]2-deoxyglucose
KW - β-Amyloid precursor protein
UR - http://www.scopus.com/inward/record.url?scp=0032735889&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(99)00847-2
DO - 10.1016/S0304-3940(99)00847-2
M3 - Article
C2 - 10643895
AN - SCOPUS:0032735889
SN - 0304-3940
VL - 277
SP - 49
EP - 52
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -