Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants

Zachary A. Vesoulis; Rachel L. Bank; Doug Lake; Aaron Wallman-Stokes; Rakesh Sahni; J. Randall Moorman; Joseph R. Isler; Karen D. Fairchild; Amit M. Mathur

doi:10.1038/s41372-018-0236-2

Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants

Zachary A. Vesoulis, Rachel L. Bank, Doug Lake, Aaron Wallman-Stokes, Rakesh Sahni, J. Randall Moorman, Joseph R. Isler, Karen D. Fairchild, Amit M. Mathur

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32 Scopus citations

Abstract

Objectives:: The objective of this study was to define the association between the burden of severe hypoxemia (SpO ₂ ≤70%) in the first week of life and development of severe ICH (grade III/IV) in preterm infants. Study design:: Infants born at <32 weeks or weighing <1500 g underwent prospective SpO ₂ recording from birth through 7 days. Severe hypoxemia burden was calculated as the percentage of the error-corrected recording where SpO ₂ ≤70%. Binary logistic regression was used to model the relationship between hypoxemia burden and severe ICH. Results:: A total of 163.3 million valid SpO ₂ data points were collected from 645 infants with mean EGA = 27.7 ± 2.6 weeks, BW = 1005 ± 291 g; 38/645 (6%) developed severe ICH. There was a greater mean hypoxemia burden for infants with severe ICH (3%) compared to those without (0.1%) and remained significant when controlling for multiple confounding factors. Conclusion:: The severe hypoxemia burden in the first week of life is strongly associated with severe ICH.

Original language	English
Pages (from-to)	48-53
Number of pages	6
Journal	Journal of Perinatology
Volume	39
Issue number	1
DOIs	https://doi.org/10.1038/s41372-018-0236-2
State	Published - Jan 1 2019

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title = "Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants",

abstract = " Objectives:: The objective of this study was to define the association between the burden of severe hypoxemia (SpO 2 ≤70%) in the first week of life and development of severe ICH (grade III/IV) in preterm infants. Study design:: Infants born at <32 weeks or weighing <1500 g underwent prospective SpO 2 recording from birth through 7 days. Severe hypoxemia burden was calculated as the percentage of the error-corrected recording where SpO 2 ≤70%. Binary logistic regression was used to model the relationship between hypoxemia burden and severe ICH. Results:: A total of 163.3 million valid SpO 2 data points were collected from 645 infants with mean EGA = 27.7 ± 2.6 weeks, BW = 1005 ± 291 g; 38/645 (6%) developed severe ICH. There was a greater mean hypoxemia burden for infants with severe ICH (3%) compared to those without (0.1%) and remained significant when controlling for multiple confounding factors. Conclusion:: The severe hypoxemia burden in the first week of life is strongly associated with severe ICH.",

author = "Vesoulis, {Zachary A.} and Bank, {Rachel L.} and Doug Lake and Aaron Wallman-Stokes and Rakesh Sahni and Moorman, {J. Randall} and Isler, {Joseph R.} and Fairchild, {Karen D.} and Mathur, {Amit M.}",

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year = "2019",

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doi = "10.1038/s41372-018-0236-2",

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T1 - Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants

AU - Vesoulis, Zachary A.

AU - Bank, Rachel L.

AU - Lake, Doug

AU - Wallman-Stokes, Aaron

AU - Sahni, Rakesh

AU - Moorman, J. Randall

AU - Isler, Joseph R.

AU - Fairchild, Karen D.

AU - Mathur, Amit M.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives:: The objective of this study was to define the association between the burden of severe hypoxemia (SpO 2 ≤70%) in the first week of life and development of severe ICH (grade III/IV) in preterm infants. Study design:: Infants born at <32 weeks or weighing <1500 g underwent prospective SpO 2 recording from birth through 7 days. Severe hypoxemia burden was calculated as the percentage of the error-corrected recording where SpO 2 ≤70%. Binary logistic regression was used to model the relationship between hypoxemia burden and severe ICH. Results:: A total of 163.3 million valid SpO 2 data points were collected from 645 infants with mean EGA = 27.7 ± 2.6 weeks, BW = 1005 ± 291 g; 38/645 (6%) developed severe ICH. There was a greater mean hypoxemia burden for infants with severe ICH (3%) compared to those without (0.1%) and remained significant when controlling for multiple confounding factors. Conclusion:: The severe hypoxemia burden in the first week of life is strongly associated with severe ICH.

AB - Objectives:: The objective of this study was to define the association between the burden of severe hypoxemia (SpO 2 ≤70%) in the first week of life and development of severe ICH (grade III/IV) in preterm infants. Study design:: Infants born at <32 weeks or weighing <1500 g underwent prospective SpO 2 recording from birth through 7 days. Severe hypoxemia burden was calculated as the percentage of the error-corrected recording where SpO 2 ≤70%. Binary logistic regression was used to model the relationship between hypoxemia burden and severe ICH. Results:: A total of 163.3 million valid SpO 2 data points were collected from 645 infants with mean EGA = 27.7 ± 2.6 weeks, BW = 1005 ± 291 g; 38/645 (6%) developed severe ICH. There was a greater mean hypoxemia burden for infants with severe ICH (3%) compared to those without (0.1%) and remained significant when controlling for multiple confounding factors. Conclusion:: The severe hypoxemia burden in the first week of life is strongly associated with severe ICH.

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JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 1

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Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants

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