Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants

Zachary A. Vesoulis, Rachel L. Bank, Doug Lake, Aaron Wallman-Stokes, Rakesh Sahni, J. Randall Moorman, Joseph R. Isler, Karen D. Fairchild, Amit M. Mathur

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4 Scopus citations

Abstract

Objectives:: The objective of this study was to define the association between the burden of severe hypoxemia (SpO 2 ≤70%) in the first week of life and development of severe ICH (grade III/IV) in preterm infants. Study design:: Infants born at <32 weeks or weighing <1500 g underwent prospective SpO 2 recording from birth through 7 days. Severe hypoxemia burden was calculated as the percentage of the error-corrected recording where SpO 2 ≤70%. Binary logistic regression was used to model the relationship between hypoxemia burden and severe ICH. Results:: A total of 163.3 million valid SpO 2 data points were collected from 645 infants with mean EGA = 27.7 ± 2.6 weeks, BW = 1005 ± 291 g; 38/645 (6%) developed severe ICH. There was a greater mean hypoxemia burden for infants with severe ICH (3%) compared to those without (0.1%) and remained significant when controlling for multiple confounding factors. Conclusion:: The severe hypoxemia burden in the first week of life is strongly associated with severe ICH.

Original languageEnglish
Pages (from-to)48-53
Number of pages6
JournalJournal of Perinatology
Volume39
Issue number1
DOIs
StatePublished - Jan 1 2019

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    Vesoulis, Z. A., Bank, R. L., Lake, D., Wallman-Stokes, A., Sahni, R., Moorman, J. R., Isler, J. R., Fairchild, K. D., & Mathur, A. M. (2019). Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants. Journal of Perinatology, 39(1), 48-53. https://doi.org/10.1038/s41372-018-0236-2