TY - JOUR
T1 - Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants
AU - Vesoulis, Zachary A.
AU - Bank, Rachel L.
AU - Lake, Doug
AU - Wallman-Stokes, Aaron
AU - Sahni, Rakesh
AU - Moorman, J. Randall
AU - Isler, Joseph R.
AU - Fairchild, Karen D.
AU - Mathur, Amit M.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Objectives:: The objective of this study was to define the association between the burden of severe hypoxemia (SpO 2 ≤70%) in the first week of life and development of severe ICH (grade III/IV) in preterm infants. Study design:: Infants born at <32 weeks or weighing <1500 g underwent prospective SpO 2 recording from birth through 7 days. Severe hypoxemia burden was calculated as the percentage of the error-corrected recording where SpO 2 ≤70%. Binary logistic regression was used to model the relationship between hypoxemia burden and severe ICH. Results:: A total of 163.3 million valid SpO 2 data points were collected from 645 infants with mean EGA = 27.7 ± 2.6 weeks, BW = 1005 ± 291 g; 38/645 (6%) developed severe ICH. There was a greater mean hypoxemia burden for infants with severe ICH (3%) compared to those without (0.1%) and remained significant when controlling for multiple confounding factors. Conclusion:: The severe hypoxemia burden in the first week of life is strongly associated with severe ICH.
AB - Objectives:: The objective of this study was to define the association between the burden of severe hypoxemia (SpO 2 ≤70%) in the first week of life and development of severe ICH (grade III/IV) in preterm infants. Study design:: Infants born at <32 weeks or weighing <1500 g underwent prospective SpO 2 recording from birth through 7 days. Severe hypoxemia burden was calculated as the percentage of the error-corrected recording where SpO 2 ≤70%. Binary logistic regression was used to model the relationship between hypoxemia burden and severe ICH. Results:: A total of 163.3 million valid SpO 2 data points were collected from 645 infants with mean EGA = 27.7 ± 2.6 weeks, BW = 1005 ± 291 g; 38/645 (6%) developed severe ICH. There was a greater mean hypoxemia burden for infants with severe ICH (3%) compared to those without (0.1%) and remained significant when controlling for multiple confounding factors. Conclusion:: The severe hypoxemia burden in the first week of life is strongly associated with severe ICH.
UR - http://www.scopus.com/inward/record.url?scp=85054394015&partnerID=8YFLogxK
U2 - 10.1038/s41372-018-0236-2
DO - 10.1038/s41372-018-0236-2
M3 - Article
C2 - 30267001
AN - SCOPUS:85054394015
VL - 39
SP - 48
EP - 53
JO - Journal of Perinatology
JF - Journal of Perinatology
SN - 0743-8346
IS - 1
ER -