TY - JOUR
T1 - Early Brain Injury After Subarachnoid Hemorrhage
T2 - Incidence and Mechanisms
AU - Lauzier, David C.
AU - Jayaraman, Keshav
AU - Yuan, Jane Y.
AU - Diwan, Deepti
AU - Vellimana, Ananth K.
AU - Osbun, Joshua W.
AU - Chatterjee, Arindam R.
AU - Athiraman, Umeshkumar
AU - Dhar, Rajat
AU - Zipfel, Gregory J.
N1 - Funding Information:
This article was funded by NINDS—R01—NS091603 (Dr Zipfel).
Funding Information:
Dr Osbun is a consultant for Medtronic, Microvention, Stryker, Terumo, and Penumbra. ARC is a consultant for Penumbra and MDReview. Dr Chatterjee and K. Jayaraman receive grant support from Washington University School of Medicine in St. Louis.
Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Aneurysmal subarachnoid hemorrhage is a devastating condition causing significant morbidity and mortality. While outcomes from subarachnoid hemorrhage have improved in recent years, there continues to be significant interest in identifying therapeutic targets for this disease. In particular, there has been a shift in emphasis toward secondary brain injury that develops in the first 72 hours after subarachnoid hemorrhage. This time period of interest is referred to as the early brain injury period and comprises processes including microcirculatory dysfunction, blood-brain-barrier breakdown, neuroinflammation, cerebral edema, oxidative cascades, and neuronal death. Advances in our understanding of the mechanisms defining the early brain injury period have been accompanied by improved imaging and nonimaging biomarkers for identifying early brain injury, leading to the recognition of an elevated clinical incidence of early brain injury compared with prior estimates. With the frequency, impact, and mechanisms of early brain injury better defined, there is a need to review the literature in this area to guide preclinical and clinical study.
AB - Aneurysmal subarachnoid hemorrhage is a devastating condition causing significant morbidity and mortality. While outcomes from subarachnoid hemorrhage have improved in recent years, there continues to be significant interest in identifying therapeutic targets for this disease. In particular, there has been a shift in emphasis toward secondary brain injury that develops in the first 72 hours after subarachnoid hemorrhage. This time period of interest is referred to as the early brain injury period and comprises processes including microcirculatory dysfunction, blood-brain-barrier breakdown, neuroinflammation, cerebral edema, oxidative cascades, and neuronal death. Advances in our understanding of the mechanisms defining the early brain injury period have been accompanied by improved imaging and nonimaging biomarkers for identifying early brain injury, leading to the recognition of an elevated clinical incidence of early brain injury compared with prior estimates. With the frequency, impact, and mechanisms of early brain injury better defined, there is a need to review the literature in this area to guide preclinical and clinical study.
KW - aneurysm
KW - secondary brain injury
KW - stroke
KW - subarachnoid hemorrhage
UR - http://www.scopus.com/inward/record.url?scp=85152940522&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.122.040072
DO - 10.1161/STROKEAHA.122.040072
M3 - Review article
C2 - 36866673
AN - SCOPUS:85152940522
SN - 0039-2499
VL - 54
SP - 1426
EP - 1440
JO - Stroke
JF - Stroke
IS - 5
ER -