Early appropriate empiric therapy and antimicrobial de-escalation

James M. Hollands; Scott T. Micek; Peggy S. McKinnon; Marin H. Kollef

Early appropriate empiric therapy and antimicrobial de-escalation

James M. Hollands, Scott T. Micek, Peggy S. McKinnon, Marin H. Kollef

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Bacterial resistance to antibiotics creates a therapeutic challenge to clinicians when treating patients with a known or suspected infection. Increasing rates of resistance lead many clinicians to empirically treat patients with multiple broadspectrum antibiotics, which can perpetuate the cycle of increasing resistance and create an economic burden to society (see Chapter 4). Conversely, inappropriate initial therapy, defined as a regimen that lacks in vitro activity against an isolated organism, can lead to treatment failures that have negative patient outcomes.

Original language	English
Title of host publication	Antimicrobial Resistance
Subtitle of host publication	Problem Pathogens and Clinical Countermeasures
Publisher	CRC Press
Pages	231-250
Number of pages	20
ISBN (Electronic)	9781420017236
ISBN (Print)	9780824729417
State	Published - Jan 1 2007

Cite this

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N2 - Bacterial resistance to antibiotics creates a therapeutic challenge to clinicians when treating patients with a known or suspected infection. Increasing rates of resistance lead many clinicians to empirically treat patients with multiple broadspectrum antibiotics, which can perpetuate the cycle of increasing resistance and create an economic burden to society (see Chapter 4). Conversely, inappropriate initial therapy, defined as a regimen that lacks in vitro activity against an isolated organism, can lead to treatment failures that have negative patient outcomes.

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Early appropriate empiric therapy and antimicrobial de-escalation

Abstract

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