Early appropriate empiric therapy and antimicrobial de-escalation

James M. Hollands, Scott T. Micek, Peggy S. McKinnon, Marin H. Kollef

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Bacterial resistance to antibiotics creates a therapeutic challenge to clinicians when treating patients with a known or suspected infection. Increasing rates of resistance lead many clinicians to empirically treat patients with multiple broadspectrum antibiotics, which can perpetuate the cycle of increasing resistance and create an economic burden to society (see Chapter 4). Conversely, inappropriate initial therapy, defined as a regimen that lacks in vitro activity against an isolated organism, can lead to treatment failures that have negative patient outcomes.

Original languageEnglish
Title of host publicationAntimicrobial Resistance
Subtitle of host publicationProblem Pathogens and Clinical Countermeasures
PublisherCRC Press
Number of pages20
ISBN (Electronic)9781420017236
ISBN (Print)9780824729417
StatePublished - Jan 1 2007


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