Early affective changes and increased connectivity in preclinical Alzheimer's disease

Carolyn A. Fredericks, Virginia E. Sturm, Jesse A. Brown, Alice Y. Hua, Murat Bilgel, Dean F. Wong, Susan M. Resnick, William W. Seeley

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Introduction: Affective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a “salience network” attuned to emotionally significant stimuli. The trajectory of affective changes in preclinical Alzheimer's disease, and its relationship to this network, is unknown. Methods: One hundred one cognitively normal older adults received longitudinal assessments of affective symptoms, then amyloid-PET. We hypothesized amyloid-positive individuals would show enhanced emotional reactivity associated with salience network connectivity. We tested whether increased global connectivity in key regions significantly related to affective changes. Results: In participants later found to be amyloid positive, emotional reactivity increased with age, and interpersonal warmth declined in women. These individuals showed higher global connectivity within the right insula and superior temporal sulcus; higher superior temporal sulcus connectivity predicted increasing emotional reactivity and decreasing interpersonal warmth. Conclusions: Affective changes should be considered an early preclinical feature of Alzheimer's disease. These changes may relate to higher functional connectivity in regions critical for social-emotional processing.

Original languageEnglish
Pages (from-to)471-479
Number of pages9
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
StatePublished - Jan 1 2018


  • Alzheimer's disease
  • Amyloid-PET
  • Functional connectivity
  • Neuropsychiatric symptoms
  • Preclinical Alzheimer's disease


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