Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system

Iftach Shaked, Ziv Porat, Roman Gersner, Jonathan Kipnis, Michal Schwartz

Research output: Contribution to journalArticlepeer-review

116 Scopus citations

Abstract

After an injury to the central nervous system (CNS), activated microglia have been shown to contribute to the ongoing destructive processes leading to secondary neuronal degeneration. They can, however, also express neuroprotective activity. Studies from our laboratory point to the existence of a physiological T cell-mediated neuroprotective mechanism (adaptive immunity) that is amenable to boosting. We postulate that the beneficial or destructive outcome of the local microglial (innate) response is determined by a well-controlled dialog between the innate and the adaptive immune players. Here, we show that spontaneous or exogenously boosted T cell-mediated neuroprotection is correlated with early activation of microglia as antigen-presenting cells. We suggest that such microglial activity, if well controlled, is a crucial step in determining the fate of the neurons in a hostile environment.

Original languageEnglish
Pages (from-to)84-93
Number of pages10
JournalJournal of Neuroimmunology
Volume146
Issue number1-2
DOIs
StatePublished - Jan 2004

Keywords

  • CNS inflammation
  • CNS trauma
  • EAE susceptibility
  • Encephalitogenicity
  • Genetic background
  • Microglia activation
  • Neuroprotection
  • Protective autoimmunity

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