Load, chamber stiffness, and relaxation are the three established determinants of global diastolic function (DF). Coupling of systolic stiffness and isovolumic relaxation has been hypothesized; however, diastolic stiffness-relaxation coupling (DSRC) remains unknown. The parametrized diastolic filling (PDF) formalism, a validated DF model incorporates DSRC. PDF model-predicted DSRC was validated by analysis of 159 Doppler E-waves from a published data set (22 healthy volunteers undergoing bicycle exercise). E-waves at varying (46-120 bpm) heart rates (HR) demonstrated variation in acceleration time (AT), deceleration time (DT), and E-wave peak velocity. AT, DT, and Epeak were converted into PDF parameters: Stiffness (k), relaxation (c), and load (xo) using published numerical methods. Univariate linear regression showed that over a twofold increase in HR, AT, and DT decrease (r =-0.44; P < 0.001 and r =-0.42; P < 0.001, respectively), while, DT/AT remains constant (r =-0.04; P = 0.67). Similarly, k increases with HR (r = 0.55; P < 0.001), while c has no significant correlation with HR (r = 0.08; P = 0.32). However, the dimensionless DSRC parameter w = c2/4k shows no significant correlation with HR (r =-0.03; P = 0.7). Furthermore, w is uniquely determined by DT/AT rather than AT or DT independently. Constancy of w in spite of a twofold increase in HR establishes that stiffness (k) and relaxation (c) are coupled and manifest via a HR-invariant parameter of E-wave asymmetry and should not be considered independent of each other. The manifestation of DSRC through E-wave asymmetry via w underscores the value of DT/AT as a physiological, mechanism-derived index of DF.
|Journal||American Journal of Physiology - Heart and Circulatory Physiology|
|State||Published - Jan 2021|
- Diastolic function
- Pdf formalism