E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis

Daniela Galimberti; Chiara Fenoglio; Raffaella Clerici; Cristoforo Comi; Milena De Riz; Mariarosa Rottoli; Laura Piccio; Marco Ronzoni; Eliana Venturelli; Francesco Monaco; Marco Poloni; Nereo Bresolin; Elio Scarpini

doi:10.1016/j.jneuroim.2005.05.003

E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis

Daniela Galimberti
, Chiara Fenoglio
, Raffaella Clerici
, Cristoforo Comi
, Milena De Riz
, Mariarosa Rottoli
, Laura Piccio
, Marco Ronzoni
, Eliana Venturelli
, Francesco Monaco
, Marco Poloni
, Nereo Bresolin
, Elio Scarpini

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.

Original language	English
Pages (from-to)	201-205
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	165
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2005.05.003
State	Published - Aug 2005

Keywords

Adhesion molecules
E-selectin
Genetics
Multiple sclerosis
Polymorphism

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10.1016/j.jneuroim.2005.05.003

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Galimberti, D., Fenoglio, C., Clerici, R., Comi, C., De Riz, M., Rottoli, M., Piccio, L., Ronzoni, M., Venturelli, E., Monaco, F., Poloni, M., Bresolin, N., & Scarpini, E. (2005). E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis. Journal of Neuroimmunology, 165(1-2), 201-205. https://doi.org/10.1016/j.jneuroim.2005.05.003

@article{a5543d1ff94f4e93abbd19f69e7ed5fa,

title = "E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis",

abstract = "Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.",

keywords = "Adhesion molecules, E-selectin, Genetics, Multiple sclerosis, Polymorphism",

author = "Daniela Galimberti and Chiara Fenoglio and Raffaella Clerici and Cristoforo Comi and \{De Riz\}, Milena and Mariarosa Rottoli and Laura Piccio and Marco Ronzoni and Eliana Venturelli and Francesco Monaco and Marco Poloni and Nereo Bresolin and Elio Scarpini",

note = "Funding Information: This work was supported by grants from Associazione “Amici del Centro Dino Ferrari”, IRCCS Ospedale Maggiore Milano, Centre of Excellence for Neurodegenerative Diseases of the University of Milan and Ing. Cesare Cusan.",

year = "2005",

month = aug,

doi = "10.1016/j.jneuroim.2005.05.003",

language = "English",

volume = "165",

pages = "201--205",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

number = "1-2",

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Galimberti, D, Fenoglio, C, Clerici, R, Comi, C, De Riz, M, Rottoli, M, Piccio, L, Ronzoni, M, Venturelli, E, Monaco, F, Poloni, M, Bresolin, N & Scarpini, E 2005, 'E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis', Journal of Neuroimmunology, vol. 165, no. 1-2, pp. 201-205. https://doi.org/10.1016/j.jneuroim.2005.05.003

TY - JOUR

T1 - E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis

AU - Galimberti, Daniela

AU - Fenoglio, Chiara

AU - Clerici, Raffaella

AU - Comi, Cristoforo

AU - De Riz, Milena

AU - Rottoli, Mariarosa

AU - Piccio, Laura

AU - Ronzoni, Marco

AU - Venturelli, Eliana

AU - Monaco, Francesco

AU - Poloni, Marco

AU - Bresolin, Nereo

AU - Scarpini, Elio

N1 - Funding Information: This work was supported by grants from Associazione “Amici del Centro Dino Ferrari”, IRCCS Ospedale Maggiore Milano, Centre of Excellence for Neurodegenerative Diseases of the University of Milan and Ing. Cesare Cusan.

PY - 2005/8

Y1 - 2005/8

N2 - Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.

AB - Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.

KW - Adhesion molecules

KW - E-selectin

KW - Genetics

KW - Multiple sclerosis

KW - Polymorphism

UR - https://www.scopus.com/pages/publications/22144490465

U2 - 10.1016/j.jneuroim.2005.05.003

DO - 10.1016/j.jneuroim.2005.05.003

M3 - Article

C2 - 15979159

AN - SCOPUS:22144490465

SN - 0165-5728

VL - 165

SP - 201

EP - 205

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis

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Keywords

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