E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis

Daniela Galimberti, Chiara Fenoglio, Raffaella Clerici, Cristoforo Comi, Milena De Riz, Mariarosa Rottoli, Laura Piccio, Marco Ronzoni, Eliana Venturelli, Francesco Monaco, Marco Poloni, Nereo Bresolin, Elio Scarpini

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18 Scopus citations

Abstract

Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalJournal of Neuroimmunology
Volume165
Issue number1-2
DOIs
StatePublished - Aug 1 2005
Externally publishedYes

Keywords

  • Adhesion molecules
  • E-selectin
  • Genetics
  • Multiple sclerosis
  • Polymorphism

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    Galimberti, D., Fenoglio, C., Clerici, R., Comi, C., De Riz, M., Rottoli, M., Piccio, L., Ronzoni, M., Venturelli, E., Monaco, F., Poloni, M., Bresolin, N., & Scarpini, E. (2005). E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis. Journal of Neuroimmunology, 165(1-2), 201-205. https://doi.org/10.1016/j.jneuroim.2005.05.003