@article{f09d824abe9047a9ae6642ecadcdc43d,
title = "DYT1 dystonia increases risk taking in humans",
abstract = "It has been difficult to link synaptic modification to overt behavioral changes. Rodent models of DYT1 dystonia, a motor disorder caused by a single gene mutation, demonstrate increased long-term potentiation and decreased long-term depression in corticostriatal synapses. Computationally, such asymmetric learning predicts risk taking in probabilistic tasks. Here we demonstrate abnormal risk taking in DYT1 dystonia patients, which is correlated with disease severity, thereby supporting striatal plasticity in shaping choice behavior in humans.",
author = "David Arkadir and Angela Radulescu and Deborah Raymond and Naomi Lubarr and Bressman, {Susan B.} and Pietro Mazzoni and Yael Niv",
note = "Funding Information: Parkinson{\textquoteright}s Disease Foundation David Arkadir. National Institutes of Health NIH Office of Rare Diseases Research through the Dystonia Coalition David Arkadir. National Institute for Psychobiology in Israel, Hebrew University of Jerusalem David Arkadir. Alfred P. Sloan Foundation Sloan Research Fellowship Yael Niv. National Institute of Mental Health R01MH098861 Angela Radulescu Yael Niv. Army Research Office W911NF-14-1-0101 Angela Radulescu Yael Niv. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publisher Copyright: {\textcopyright} Arkadir et al.",
year = "2016",
month = jun,
day = "1",
doi = "10.7554/eLife.14155",
language = "English",
volume = "5",
journal = "eLife",
issn = "2050-084X",
number = "JUN2016",
}