Dysregulation of angiopoietin 1 and 2 in escherichia coli O157:H7 Infection and the hemolytic-uremic syndrome

Andrea V. Page, Phillip I. Tarr, Sandra L. Watkins, Nimerta Rajwans, Tania N. Petruzziello-Pellegrini, Philip A. Marsden, Kevin C. Kain, W. Conrad Liles

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Escherichia coli O157:H7-associated hemolytic-uremic syndrome (HUS) is characterized by profound prothrombotic abnormalities. Endothelial dysfunction, manifested as dysregulation of angiopoietins 1 and 2 (Ang-1/2), could underlie HUS pathophysiology. We measured Ang-1/2 in 77 children with E. coli O157:H7 infection. Ang-1, Ang-2, and the Ang-2/Ang-1 ratio were significantly different in HUS vs the pre-HUS phase of illness or uncomplicated infection. Angiopoietin dysregulation preceded HUS and worsened as HUS developed. In vitro exposure of human microvascular endothelial cells to Shiga toxin recapitulated the in vivo observations. Angiopoietin regulation is profoundly affected before and during HUS, reflecting that subclinical endothelial dysfunction precedes overt microangiopathy.

Original languageEnglish
Pages (from-to)929-933
Number of pages5
JournalJournal of Infectious Diseases
Volume208
Issue number6
DOIs
StatePublished - Sep 15 2013

Keywords

  • E. coli O157:H7
  • angiopoietin 1
  • angiopoietin 2
  • endothelial dysfunction
  • hemolytic-uremic syndrome

Fingerprint

Dive into the research topics of 'Dysregulation of angiopoietin 1 and 2 in escherichia coli O157:H7 Infection and the hemolytic-uremic syndrome'. Together they form a unique fingerprint.

Cite this