@article{3689cd1b355b48568fc809b47a680146,
title = "Dysregulation of angiopoietin 1 and 2 in escherichia coli O157:H7 Infection and the hemolytic-uremic syndrome",
abstract = "Escherichia coli O157:H7-associated hemolytic-uremic syndrome (HUS) is characterized by profound prothrombotic abnormalities. Endothelial dysfunction, manifested as dysregulation of angiopoietins 1 and 2 (Ang-1/2), could underlie HUS pathophysiology. We measured Ang-1/2 in 77 children with E. coli O157:H7 infection. Ang-1, Ang-2, and the Ang-2/Ang-1 ratio were significantly different in HUS vs the pre-HUS phase of illness or uncomplicated infection. Angiopoietin dysregulation preceded HUS and worsened as HUS developed. In vitro exposure of human microvascular endothelial cells to Shiga toxin recapitulated the in vivo observations. Angiopoietin regulation is profoundly affected before and during HUS, reflecting that subclinical endothelial dysfunction precedes overt microangiopathy.",
keywords = "E. coli O157:H7, angiopoietin 1, angiopoietin 2, endothelial dysfunction, hemolytic-uremic syndrome",
author = "Page, {Andrea V.} and Tarr, {Phillip I.} and Watkins, {Sandra L.} and Nimerta Rajwans and Petruzziello-Pellegrini, {Tania N.} and Marsden, {Philip A.} and Kain, {Kevin C.} and {Conrad Liles}, W.",
note = "Funding Information: Financial support. This work was supported by the University of Toronto Department of Medicine Clinician-Scientist Training Program (to A.V.P.); the McLaughlin Centre for Molecular Medicine (to W.C.L.); the Canadian Institutes of Health Research (CIHR) Canada Research Chair program (to W.C.L. and K.C.K); CIHR Team Grant in Malaria (to K.C.K.), CIHR (grant numbers MOP-13721, 115160 to K.C.K.); Genome Canada through the Ontario Genomics Institute (to K.C.K.); the Defense Advanced Research Projects Agency (grant number 58217-LS-DRP to K.C.K.); the National Institutes of Health (grant number DK52081 to P.I.T. and P30 DK052574 to Washington University Digestive Diseases Research Core Center, Biobank Core); and the Melvin E. Carnahan Professorship in Pediatrics (to P.I.T.).",
year = "2013",
month = sep,
day = "15",
doi = "10.1093/infdis/jit268",
language = "English",
volume = "208",
pages = "929--933",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
number = "6",
}