Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization

Véronique Angeli, Jaime Llodrá, James X. Rong, Kei Satoh, Satoshi Ishii, Takao Shimizu, Edward A. Fisher, Gwendalyn J. Randolph

Research output: Contribution to journalArticlepeer-review

212 Scopus citations

Abstract

High LDL and/or low HDL are risk factors for atherosclerosis and are also a common clinical feature in systemic lupus erythematosus, rheumatoid arthritis, and psoriasis. Here, we show that changes in lipid profiles that reflect atherosclerotic disease led to activation of skin murine dendritic cells (DCs) locally, promoted dermal inflammation, and induced lymph node hypertrophy. Paradoxically, DC migration to lymph nodes was impaired, suppressing immunologic priming. Impaired migration resulted from inhibitory signals generated by platelet-activating factor (PAF) or oxidized LDL that acts as a PAF mimetic. Normal DC migration and priming was restored by HDL or HDL-associated PAF acetylhydrolase (PAFAH), which mediates inactivation of PAF and oxidized LDL. Thus, atherosclerotic changes can sequester activated DCs in the periphery where they may aggravate local inflammation even as they poorly carry out functions that require their migration to lymph nodes. In this context, HDL and PAFAH maintain a normally functional DC compartment.

Original languageEnglish
Pages (from-to)561-574
Number of pages14
JournalImmunity
Volume21
Issue number4
DOIs
StatePublished - Oct 2004

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