Dynamic whole-body PET imaging: principles, potentials and applications

Arman Rahmim; Martin A. Lodge; Nicolas A. Karakatsanis; Vladimir Y. Panin; Yun Zhou; Alan McMillan; Steve Cho; Habib Zaidi; Michael E. Casey; Richard L. Wahl

doi:10.1007/s00259-018-4153-6

Dynamic whole-body PET imaging: principles, potentials and applications

Arman Rahmim, Martin A. Lodge, Nicolas A. Karakatsanis, Vladimir Y. Panin, Yun Zhou, Alan McMillan, Steve Cho, Habib Zaidi, Michael E. Casey, Richard L. Wahl

Research output: Contribution to journal › Review article › peer-review

171 Scopus citations

Abstract

Purpose: In this article, we discuss dynamic whole-body (DWB) positron emission tomography (PET) as an imaging tool with significant clinical potential, in relation to conventional standard uptake value (SUV) imaging. Background: DWB PET involves dynamic data acquisition over an extended axial range, capturing tracer kinetic information that is not available with conventional static acquisition protocols. The method can be performed within reasonable clinical imaging times, and enables generation of multiple types of PET images with complementary information in a single imaging session. Importantly, DWB PET can be used to produce multi-parametric images of (i) Patlak slope (influx rate) and (ii) intercept (referred to sometimes as “distribution volume”), while also providing (iii) a conventional ‘SUV-equivalent’ image for certain protocols. Results: We provide an overview of ongoing efforts (primarily focused on FDG PET) and discuss potential clinically relevant applications. Conclusion: Overall, the framework of DWB imaging [applicable to both PET/CT(computed tomography) and PET/MRI (magnetic resonance imaging)] generates quantitative measures that may add significant value to conventional SUV image-derived measures, with limited pitfalls as we also discuss in this work.

Original language	English
Pages (from-to)	501-518
Number of pages	18
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	46
Issue number	2
DOIs	https://doi.org/10.1007/s00259-018-4153-6
State	Published - Feb 1 2019

Keywords

Dynamic
Kinetic modeling
PET
Parametric imaging
Systemic disease
Whole-body

Access to Document

10.1007/s00259-018-4153-6

Cite this

@article{51a5817f4df94f49b08aa0ac23704905,

title = "Dynamic whole-body PET imaging: principles, potentials and applications",

abstract = "Purpose: In this article, we discuss dynamic whole-body (DWB) positron emission tomography (PET) as an imaging tool with significant clinical potential, in relation to conventional standard uptake value (SUV) imaging. Background: DWB PET involves dynamic data acquisition over an extended axial range, capturing tracer kinetic information that is not available with conventional static acquisition protocols. The method can be performed within reasonable clinical imaging times, and enables generation of multiple types of PET images with complementary information in a single imaging session. Importantly, DWB PET can be used to produce multi-parametric images of (i) Patlak slope (influx rate) and (ii) intercept (referred to sometimes as “distribution volume”), while also providing (iii) a conventional {\textquoteleft}SUV-equivalent{\textquoteright} image for certain protocols. Results: We provide an overview of ongoing efforts (primarily focused on FDG PET) and discuss potential clinically relevant applications. Conclusion: Overall, the framework of DWB imaging [applicable to both PET/CT(computed tomography) and PET/MRI (magnetic resonance imaging)] generates quantitative measures that may add significant value to conventional SUV image-derived measures, with limited pitfalls as we also discuss in this work.",

keywords = "Dynamic, Kinetic modeling, PET, Parametric imaging, Systemic disease, Whole-body",

author = "Arman Rahmim and Lodge, {Martin A.} and Karakatsanis, {Nicolas A.} and Panin, {Vladimir Y.} and Yun Zhou and Alan McMillan and Steve Cho and Habib Zaidi and Casey, {Michael E.} and Wahl, {Richard L.}",

note = "Publisher Copyright: {\textcopyright} 2018, Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2019",

month = feb,

day = "1",

doi = "10.1007/s00259-018-4153-6",

language = "English",

volume = "46",

pages = "501--518",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

number = "2",

}

TY - JOUR

T1 - Dynamic whole-body PET imaging

T2 - principles, potentials and applications

AU - Rahmim, Arman

AU - Lodge, Martin A.

AU - Karakatsanis, Nicolas A.

AU - Panin, Vladimir Y.

AU - Zhou, Yun

AU - McMillan, Alan

AU - Cho, Steve

AU - Zaidi, Habib

AU - Casey, Michael E.

AU - Wahl, Richard L.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Purpose: In this article, we discuss dynamic whole-body (DWB) positron emission tomography (PET) as an imaging tool with significant clinical potential, in relation to conventional standard uptake value (SUV) imaging. Background: DWB PET involves dynamic data acquisition over an extended axial range, capturing tracer kinetic information that is not available with conventional static acquisition protocols. The method can be performed within reasonable clinical imaging times, and enables generation of multiple types of PET images with complementary information in a single imaging session. Importantly, DWB PET can be used to produce multi-parametric images of (i) Patlak slope (influx rate) and (ii) intercept (referred to sometimes as “distribution volume”), while also providing (iii) a conventional ‘SUV-equivalent’ image for certain protocols. Results: We provide an overview of ongoing efforts (primarily focused on FDG PET) and discuss potential clinically relevant applications. Conclusion: Overall, the framework of DWB imaging [applicable to both PET/CT(computed tomography) and PET/MRI (magnetic resonance imaging)] generates quantitative measures that may add significant value to conventional SUV image-derived measures, with limited pitfalls as we also discuss in this work.

AB - Purpose: In this article, we discuss dynamic whole-body (DWB) positron emission tomography (PET) as an imaging tool with significant clinical potential, in relation to conventional standard uptake value (SUV) imaging. Background: DWB PET involves dynamic data acquisition over an extended axial range, capturing tracer kinetic information that is not available with conventional static acquisition protocols. The method can be performed within reasonable clinical imaging times, and enables generation of multiple types of PET images with complementary information in a single imaging session. Importantly, DWB PET can be used to produce multi-parametric images of (i) Patlak slope (influx rate) and (ii) intercept (referred to sometimes as “distribution volume”), while also providing (iii) a conventional ‘SUV-equivalent’ image for certain protocols. Results: We provide an overview of ongoing efforts (primarily focused on FDG PET) and discuss potential clinically relevant applications. Conclusion: Overall, the framework of DWB imaging [applicable to both PET/CT(computed tomography) and PET/MRI (magnetic resonance imaging)] generates quantitative measures that may add significant value to conventional SUV image-derived measures, with limited pitfalls as we also discuss in this work.

KW - Dynamic

KW - Kinetic modeling

KW - PET

KW - Parametric imaging

KW - Systemic disease

KW - Whole-body

UR - http://www.scopus.com/inward/record.url?scp=85060062783&partnerID=8YFLogxK

U2 - 10.1007/s00259-018-4153-6

DO - 10.1007/s00259-018-4153-6

M3 - Review article

C2 - 30269154

AN - SCOPUS:85060062783

SN - 1619-7070

VL - 46

SP - 501

EP - 518

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 2

ER -

Dynamic whole-body PET imaging: principles, potentials and applications

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this