Hepatic macrophages are thought to be essential in the pathogenesis of NASH; however, the underlying mechanisms remain unclear. Daemen et al. demonstrate infiltration of distinct populations of recruited monocyte-derived macrophages in the NASH liver, which form hepatic crown-like structures and influence tissue fibrosis.

Original languageEnglish
Article number108626
JournalCell Reports
Issue number2
StatePublished - Jan 12 2021


  • CCR2
  • Cx3cr1
  • Kupffer cells
  • crown-like structures
  • diabetes
  • fibrosis
  • inflammation
  • lipid-associated macrophages
  • liver


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