@article{9c320013de8f4125bd966b4239da976b,
title = "Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH",
abstract = "Hepatic macrophages are thought to be essential in the pathogenesis of NASH; however, the underlying mechanisms remain unclear. Daemen et al. demonstrate infiltration of distinct populations of recruited monocyte-derived macrophages in the NASH liver, which form hepatic crown-like structures and influence tissue fibrosis.",
keywords = "CCR2, Cx3cr1, Kupffer cells, crown-like structures, diabetes, fibrosis, inflammation, lipid-associated macrophages, liver",
author = "Sabine Daemen and Anastasiia Gainullina and Gowri Kalugotla and Li He and Chan, {Mandy M.} and Beals, {Joseph W.} and Liss, {Kim H.} and Samuel Klein and Feldstein, {Ariel E.} and Finck, {Brian N.} and Artyomov, {Maxim N.} and Schilling, {Joel D.}",
note = "Funding Information: This work was supported by NIH grants RO1 DK11003401 (J.D.S.), ADA 118-IBS280 (J.D.S.), and R01 DK104735 (B.N.F.) and support from the Pershing Square Foundation (S.K.). The core services of the Diabetes Research Center (P30 DK020579) and the Nutrition and Obesity Research Center (P30 DK56341) at Washington University School of Medicine also supported this work. Conceptualization, S.D. G.K. and J.D.S.; Methodology S.D. G.K. A.G. M.A. and J.D.S.; Investigation, S.D. A.G. G.K. L.H. M.C. J.B. K.H.L. and J.D.S.; Writing ? Original Draft, J.D.S.; Writing ? Review & Editing, S.D. A.G. J.W.B. S.K. B.N.F. M.A. and J.D.S.; Revision Experiments, Review, and Editing, S.D. A.G. A.E.F. and J.D.S. A.E.F. is co-inventor on pending and issued patents filed by the Cleveland Clinic and UCSD that refer to the use of biomarkers and therapies in inflammatory and fibrotic disorders. Scientific Founder: Jecure Therapeutics, Elgia Therapeutics. Consultant/Advisory Board: Gilead, GSK, Merck, Ferring Pharmaceutical, Centurion BioPharma, Oppilan Pharma. The remaining authors have no interests to declare. Funding Information: This work was supported by NIH grants RO1 DK11003401 (J.D.S.), ADA 118-IBS280 (J.D.S.), and R01 DK104735 (B.N.F.) and support from the Pershing Square Foundation (S.K.). The core services of the Diabetes Research Center ( P30 DK020579 ) and the Nutrition and Obesity Research Center ( P30 DK56341 ) at Washington University School of Medicine also supported this work. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2021",
month = jan,
day = "12",
doi = "10.1016/j.celrep.2020.108626",
language = "English",
volume = "34",
journal = "Cell Reports",
issn = "2211-1247",
number = "2",
}