Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

Sabine Daemen, Anastasiia Gainullina, Gowri Kalugotla, Li He, Mandy M. Chan, Joseph W. Beals, Kim H. Liss, Samuel Klein, Ariel E. Feldstein, Brian N. Finck, Maxim N. Artyomov, Joel D. Schilling

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Hepatic macrophages are thought to be essential in the pathogenesis of NASH; however, the underlying mechanisms remain unclear. Daemen et al. demonstrate infiltration of distinct populations of recruited monocyte-derived macrophages in the NASH liver, which form hepatic crown-like structures and influence tissue fibrosis.

Original languageEnglish
Article number108626
JournalCell Reports
Volume34
Issue number2
DOIs
StatePublished - Jan 12 2021

Keywords

  • CCR2
  • Cx3cr1
  • Kupffer cells
  • crown-like structures
  • diabetes
  • fibrosis
  • inflammation
  • lipid-associated macrophages
  • liver

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