Dynamic kinetic resolution of azlactones catalyzed by chiral Brønsted acids

Guojian Lu; Vladimir B. Birman

doi:10.1021/ol102736t

Dynamic kinetic resolution of azlactones catalyzed by chiral Brønsted acids

Guojian Lu
, Vladimir B. Birman

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Chiral Brønsted acids have been shown for the first time to catalyze the dynamic kinetic resolution of azlactones. 3,3'-Bis-(9-anthryl)-BINOL phosphoric acid 3c is particularly effective in the case of 4-aryl-substituted substrates, producing 85-92% ee's.

Original language	English
Pages (from-to)	356-358
Number of pages	3
Journal	Organic Letters
Volume	13
Issue number	3
DOIs	https://doi.org/10.1021/ol102736t
State	Published - Feb 4 2011

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title = "Dynamic kinetic resolution of azlactones catalyzed by chiral Br{\o}nsted acids",

abstract = "Chiral Br{\o}nsted acids have been shown for the first time to catalyze the dynamic kinetic resolution of azlactones. 3,3'-Bis-(9-anthryl)-BINOL phosphoric acid 3c is particularly effective in the case of 4-aryl-substituted substrates, producing 85-92\% ee's.",

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AU - Lu, Guojian

AU - Birman, Vladimir B.

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N2 - Chiral Brønsted acids have been shown for the first time to catalyze the dynamic kinetic resolution of azlactones. 3,3'-Bis-(9-anthryl)-BINOL phosphoric acid 3c is particularly effective in the case of 4-aryl-substituted substrates, producing 85-92% ee's.

AB - Chiral Brønsted acids have been shown for the first time to catalyze the dynamic kinetic resolution of azlactones. 3,3'-Bis-(9-anthryl)-BINOL phosphoric acid 3c is particularly effective in the case of 4-aryl-substituted substrates, producing 85-92% ee's.

UR - https://www.scopus.com/pages/publications/79851477030

U2 - 10.1021/ol102736t

DO - 10.1021/ol102736t

M3 - Article

AN - SCOPUS:79851477030

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VL - 13

SP - 356

EP - 358

JO - Organic Letters

JF - Organic Letters

IS - 3

ER -

Dynamic kinetic resolution of azlactones catalyzed by chiral Brønsted acids

Abstract

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