Dynamic Decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina

Julia B. Cordero, David E. Larson, Caroline R. Craig, Rebecca Hays, Ross Cagan

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The correct organization of cells within an epithelium is essential for proper tissue and organ morphogenesis. The role of Decapentaplegic/Bone morphogenetic protein (Dpp/BMP) signaling in cellular morphogenesis during epithelial development is poorly understood. In this paper, we used the developing Drosophila pupal retina - looking specifically at the reorganization of glial-like support cells that lie between the retinal ommatidia - to better understand the role of Dpp signaling during epithelial patterning. Our results indicate that Dpp pathway activity is tightly regulated across time in the pupal retina and that epithelial cells in this tissue require Dpp signaling to achieve their correct shape and position within the ommatidial hexagon. These results point to the Dpp pathway as a third component and functional link between two adhesion systems, Hibris-Roughest and DE-cadherin. A balanced interplay between these three systems is essential for epithelial patterning during morphogenesis of the pupal retina. Importantly, we identify a similar functional connection between Dpp activity and DE-cadherin and Rho1 during cell fate determination in the wing, suggesting a broader link between Dpp function and junctional integrity during epithelial development.

Original languageEnglish
Pages (from-to)1861-1871
Number of pages11
JournalDevelopment
Volume134
Issue number10
DOIs
StatePublished - May 1 2007

Keywords

  • Adhesion
  • BMP
  • Dpp
  • Epithelia
  • Patterning

Fingerprint Dive into the research topics of 'Dynamic Decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina'. Together they form a unique fingerprint.

  • Cite this