TY - JOUR
T1 - During ontogeny, Ia-bearing accessory cells are found early in the thymus but late in the spleen
AU - Lu, C. Y.
AU - Beller, D. I.
AU - Unanue, E. R.
PY - 1980
Y1 - 1980
N2 - The ontogeny of Ia-bearing accessory cells was studied in mice. Ia-bearing adherent cells from the thymus, consisting predominantly of macrophages, were found from birth. These adherent cells were able to present antigen, as measured by their ability to induce immune T-cell proliferation. In contrast, Ia-bearing adherent cells from the spleen were not found until the second week of life, and their antigen-presentation function was not present until later. The differential ontogeny of Ia-bearing accessory cells at these sites may be important in both development of immune competence and the restriction of autoimmunity.
AB - The ontogeny of Ia-bearing accessory cells was studied in mice. Ia-bearing adherent cells from the thymus, consisting predominantly of macrophages, were found from birth. These adherent cells were able to present antigen, as measured by their ability to induce immune T-cell proliferation. In contrast, Ia-bearing adherent cells from the spleen were not found until the second week of life, and their antigen-presentation function was not present until later. The differential ontogeny of Ia-bearing accessory cells at these sites may be important in both development of immune competence and the restriction of autoimmunity.
UR - http://www.scopus.com/inward/record.url?scp=0018896548&partnerID=8YFLogxK
U2 - 10.1073/pnas.77.3.1597
DO - 10.1073/pnas.77.3.1597
M3 - Article
C2 - 6929512
AN - SCOPUS:0018896548
SN - 0027-8424
VL - 77
SP - 1597
EP - 1601
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 3 I
ER -