Dupuytren's disease: Comparative growth dynamics and morphology between cultured myofibroblasts (nodule) and fibroblasts (cord)

Jerry S.Vande Berg, Richard H. Gelberman, Ross Rudolph, Duane Johnson, Paula Sicurello

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

The excised palmar fascia of 11 patients with Dupuytren's disease was separated clinically into nodules and cords. Myofibroblasts were seen by light and electron microscopy in each of the nodules, but the cords generally lacked myofibroblasts. Only one cord specimen had microscopic features that were intermediate between nodule and cord. Electron microscopy demonstrated that in vivo differences between myofibroblasts from nodules and fibroblasts from cords and control skin samples could be preserved in vitro. Growth studies showed slower growth of cultured myofibroblasts (mean ± SD generation time 68.7 ± 15 h) than cord‐derived fibroblasts (mean ± SD generation time 51.5 ± 0.9 h). These data suggest that the life cycle of the myofibroblasts from Dupuytren's disease nodules differs from that of fibroblasts found in cordlike tissues. These myofibroblasts have biological characteristics nearly identical to those of myofibroblasts found in other contracting tissues, such as granulating wounds and breast cancer.

Original languageEnglish
Pages (from-to)247-256
Number of pages10
JournalJournal of Orthopaedic Research
Volume2
Issue number3
DOIs
StatePublished - 1984

Keywords

  • Cord
  • Dupuytren's disease
  • Nodule
  • Tissue culture

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