Dual threat: VSIG4⁺ macrophages use IL-11 and VSIG4 to silence T cells

Darya Khantakova; Marco Colonna

doi:10.1016/j.devcel.2025.08.006

Dual threat: VSIG4⁺ macrophages use IL-11 and VSIG4 to silence T cells

Darya Khantakova
, Marco Colonna

Research output: Contribution to journal › Comment/debate

Abstract

In this issue of Developmental Cell, Ma et al. show that embryonically derived VSIG4⁺ macrophages suppress CD8⁺ T cell responses across cancers. They identify IL-11 as a key effector and MEF2C as a transcriptional regulator of VSIG4⁺ macrophages, highlighting new therapeutic avenues for targeting immunosuppressive tumor-associated macrophages to improve immunotherapy outcomes.

Original language	English
Pages (from-to)	2539-2541
Number of pages	3
Journal	Developmental cell
Volume	60
Issue number	19
DOIs	https://doi.org/10.1016/j.devcel.2025.08.006
State	Published - Oct 6 2025

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10.1016/j.devcel.2025.08.006

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title = "Dual threat: VSIG4⁺ macrophages use IL-11 and VSIG4 to silence T cells",

abstract = "In this issue of Developmental Cell, Ma et al. show that embryonically derived VSIG4⁺ macrophages suppress CD8⁺ T cell responses across cancers. They identify IL-11 as a key effector and MEF2C as a transcriptional regulator of VSIG4⁺ macrophages, highlighting new therapeutic avenues for targeting immunosuppressive tumor-associated macrophages to improve immunotherapy outcomes.",

author = "Darya Khantakova and Marco Colonna",

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year = "2025",

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T2 - VSIG4⁺ macrophages use IL-11 and VSIG4 to silence T cells

AU - Khantakova, Darya

AU - Colonna, Marco

PY - 2025/10/6

Y1 - 2025/10/6

N2 - In this issue of Developmental Cell, Ma et al. show that embryonically derived VSIG4⁺ macrophages suppress CD8⁺ T cell responses across cancers. They identify IL-11 as a key effector and MEF2C as a transcriptional regulator of VSIG4⁺ macrophages, highlighting new therapeutic avenues for targeting immunosuppressive tumor-associated macrophages to improve immunotherapy outcomes.

AB - In this issue of Developmental Cell, Ma et al. show that embryonically derived VSIG4⁺ macrophages suppress CD8⁺ T cell responses across cancers. They identify IL-11 as a key effector and MEF2C as a transcriptional regulator of VSIG4⁺ macrophages, highlighting new therapeutic avenues for targeting immunosuppressive tumor-associated macrophages to improve immunotherapy outcomes.

UR - https://www.scopus.com/pages/publications/105017445447

U2 - 10.1016/j.devcel.2025.08.006

DO - 10.1016/j.devcel.2025.08.006

M3 - Comment/debate

C2 - 41056904

AN - SCOPUS:105017445447

SN - 1534-5807

VL - 60

SP - 2539

EP - 2541

JO - Developmental cell

JF - Developmental cell

IS - 19

ER -

Dual threat: VSIG4⁺ macrophages use IL-11 and VSIG4 to silence T cells

Abstract

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