Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events

Erica M. Selva, Kyoungja Hong, Gyeong Hun Baeg, Stephen M. Beverley, Salvatore J. Turco, Norbert Perrimon, Udo Häcker

Research output: Contribution to journalArticlepeer-review

107 Scopus citations

Abstract

The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucleotide-sugar transporter that transfers UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose from the cytoplasm into the lumen of the endoplasmic reticulum/Golgi. Embryos with the frc mutation display defects in Wingless, Hedgehog and fibroblast growth factor signalling. Clonal analysis shows that fringe-dependent Notch signalling is disrupted in frc mutant tissue.

Original languageEnglish
Pages (from-to)809-815
Number of pages7
JournalNature Cell Biology
Volume3
Issue number9
DOIs
StatePublished - 2001

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