@article{9050dc4f47a7464d8b10c44d197bb9ea,
title = "Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events",
abstract = "The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucleotide-sugar transporter that transfers UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose from the cytoplasm into the lumen of the endoplasmic reticulum/Golgi. Embryos with the frc mutation display defects in Wingless, Hedgehog and fibroblast growth factor signalling. Clonal analysis shows that fringe-dependent Notch signalling is disrupted in frc mutant tissue.",
author = "Selva, {Erica M.} and Kyoungja Hong and Baeg, {Gyeong Hun} and Beverley, {Stephen M.} and Turco, {Salvatore J.} and Norbert Perrimon and Udo H{\"a}cker",
note = "Funding Information: ACKNOWLEDGEMENTS We thank M. Zeidler, B. Stronach and K. Br{\"u}ckner for comments on the manuscript, and C. Hirschberg, C. Abeijon, P. Berninsone, S. Cherry, K. Nybakken and I. The for helpful discussions. Special thanks to K. Irvine, S. Artananis-Tsakonas and J. de Celis for stocks, S. Baumgartner for the Dally-like antibody, H. Agaisse for help with the northern analysis, and C. Hartmann for performing the plasmid rescue experiments. N.P. is an Investigator of the Howard Hughes Medical Institute. This work was supported by NIH Grant AI31078 (S.J.T. and S.M.B.) and GM61110 (N.P.), as well as HFSP (N.P.). Correspondence and requests for materials should be addressed to N.P.",
year = "2001",
doi = "10.1038/ncb0901-809",
language = "English",
volume = "3",
pages = "809--815",
journal = "Nature Cell Biology",
issn = "1465-7392",
number = "9",
}