Dual-radiolabeled nanoparticle SPECT probes for bioimaging

Kvar C.L. Black, Walter J. Akers, Gail Sudlow, Baogang Xu, Richard Laforest, Samuel Achilefu

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

A gold nanoparticle was radiolabeled with 125I and 111In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression. This journal is

Original languageEnglish
Pages (from-to)440-444
Number of pages5
JournalNanoscale
Volume7
Issue number2
DOIs
StatePublished - Jan 14 2015

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