TY - JOUR
T1 - Dual functionality of phosphonic-acid-appended phthalocyanines
T2 - Inhibitors of urokinase plasminogen activator and anticancer photodynamic agents
AU - Venkatramaiah, N.
AU - Pereira, Patrícia M.R.
AU - Almeida Paz, Filipe A.
AU - Ribeiro, Carlos A.F.
AU - Fernandes, Rosa
AU - Tomé, João P.C.
N1 - Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2015
Y1 - 2015
N2 - Phthalocyanines (Pcs) bearing phosphonic acid groups at the periphery exhibit a potential photodynamic effect to induce phototoxicity on human bladder cancer epithelial cells (UM-UC-3). In vitro photophysical and biological studies show high intrinsic ability to inhibit the activity of urokinase plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9).
AB - Phthalocyanines (Pcs) bearing phosphonic acid groups at the periphery exhibit a potential photodynamic effect to induce phototoxicity on human bladder cancer epithelial cells (UM-UC-3). In vitro photophysical and biological studies show high intrinsic ability to inhibit the activity of urokinase plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9).
UR - http://www.scopus.com/inward/record.url?scp=84944226537&partnerID=8YFLogxK
U2 - 10.1039/c5cc06561e
DO - 10.1039/c5cc06561e
M3 - Article
C2 - 26352730
AN - SCOPUS:84944226537
SN - 1359-7345
VL - 51
SP - 15550
EP - 15553
JO - Chemical Communications
JF - Chemical Communications
IS - 85
ER -