Drug loaded multilayered gold nanorods for combined photothermal and chemotherapy

Haiyan Chen, Xuemei Chi, Bowen Li, Min Zhang, Yuxiang Ma, Samuel Achilefu, Yueqing Gu

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

In this study, gold nanorods (AuNRs) were first stabilized by hexadecyltrimethylammonium bromide (CTAB) and then coated with two kinds of polyelectrolytes (PE) and BSA to obtain multi-layered AuNRs (AuNRs-PE-BSA). Furthermore, the anti-cancer drug doxorubicin (DOX) was encapsulated into AuNRs-PE-BSA by the electrostatic force and the nanocomposites formed were named AuNRs/DOX-PE-BSA. The success of coating was verified by transmission electron microscopy (TEM), zeta potential, gel-electrophoresis and thermogravimetric analysis (TGA). The MTT assay indicated that the cytotoxicity of AuNRs decreased dramatically after multi-layer capping. The time-dependent nucleus-targeting capability of AuNRs/DOX-PE-BSA was confirmed in cell affinity evaluations. The in vitro and in vivo experiments demonstrated that AuNRs/DOX-PE-BSA, which combined photothermal and chemotherapy for tumor therapy, bears a markedly improved curative effect and holds promising prospects in the field of nanomedicine.

Original languageEnglish
Pages (from-to)996-1006
Number of pages11
JournalBiomaterials Science
Volume2
Issue number7
DOIs
StatePublished - Jul 2014

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