TY - JOUR
T1 - Drug-evoked synaptic plasticity
T2 - Beyond metaplasticity
AU - Creed, Meaghan C.
AU - Lüscher, Christian
PY - 2013/8
Y1 - 2013/8
N2 - Addictive drugs such as cocaine induce synaptic plasticity in the ventral tegmental area and its projection areas, which may represent the cellular correlate of an addiction trace. Cocaine induces changes in excitatory transmission primarily in the VTA, which persists for days after a single exposure. These initial alterations in synaptic transmission represent a metaplasticity that is permissive for late stages of remodeling throughout the mesocorticolimbic circuitry, specifically in the NAc. Specific synaptic and cellular changes in the NAc persist following prolonged exposure to cocaine, and this remodeling may contribute to altered behavior. By manipulating synaptic activity in the NAc, it may be possible to reverse pathological synaptic transmission and its associated abnormal behavior following exposure to addictive drugs.
AB - Addictive drugs such as cocaine induce synaptic plasticity in the ventral tegmental area and its projection areas, which may represent the cellular correlate of an addiction trace. Cocaine induces changes in excitatory transmission primarily in the VTA, which persists for days after a single exposure. These initial alterations in synaptic transmission represent a metaplasticity that is permissive for late stages of remodeling throughout the mesocorticolimbic circuitry, specifically in the NAc. Specific synaptic and cellular changes in the NAc persist following prolonged exposure to cocaine, and this remodeling may contribute to altered behavior. By manipulating synaptic activity in the NAc, it may be possible to reverse pathological synaptic transmission and its associated abnormal behavior following exposure to addictive drugs.
UR - http://www.scopus.com/inward/record.url?scp=84881023062&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2013.03.005
DO - 10.1016/j.conb.2013.03.005
M3 - Review article
C2 - 23571119
AN - SCOPUS:84881023062
SN - 0959-4388
VL - 23
SP - 553
EP - 558
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 4
ER -