Drosophila aging 2006/2007

Paul Shaw; Karen Ocorr; Rolf Bodmer; Sean Oldham

doi:10.1016/j.exger.2007.10.008

Drosophila aging 2006/2007

Paul Shaw, Karen Ocorr, Rolf Bodmer, Sean Oldham

Research output: Contribution to journal › Short survey › peer-review

28 Scopus citations

Abstract

Research on aging in Drosophila continues to provide new insights into this complex process. Drosophila is highly amenable to study aging because of its short generation time, comprehensive resources for genetic manipulation, and functionally conserved physiology. Importantly, many of these physiological processes such as heart function, sleep, and metabolism functionally senescence in older flies. As the evolutionarily conserved insulin and TOR pathways are critical regulators of aging, the influence of insulin and TOR signaling on these processes is an important area for future research. An important emerging theme is determining the age-dependent alterations that occur at the organ level and how this functional senescence is regulated by different tissues.

Original language	English
Pages (from-to)	5-10
Number of pages	6
Journal	Experimental Gerontology
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/j.exger.2007.10.008
State	Published - Jan 2008

Keywords

Arrhythmia
Cardiac aging
Circadian rhythm
Dietary restriction
Endocrine systems
Heart disease
Heart failure
Insulin
KCNQ
Senescence
Sleep
TOR

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10.1016/j.exger.2007.10.008

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title = "Drosophila aging 2006/2007",

abstract = "Research on aging in Drosophila continues to provide new insights into this complex process. Drosophila is highly amenable to study aging because of its short generation time, comprehensive resources for genetic manipulation, and functionally conserved physiology. Importantly, many of these physiological processes such as heart function, sleep, and metabolism functionally senescence in older flies. As the evolutionarily conserved insulin and TOR pathways are critical regulators of aging, the influence of insulin and TOR signaling on these processes is an important area for future research. An important emerging theme is determining the age-dependent alterations that occur at the organ level and how this functional senescence is regulated by different tissues.",

keywords = "Arrhythmia, Cardiac aging, Circadian rhythm, Dietary restriction, Endocrine systems, Heart disease, Heart failure, Insulin, KCNQ, Senescence, Sleep, TOR",

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AU - Ocorr, Karen

AU - Bodmer, Rolf

AU - Oldham, Sean

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AB - Research on aging in Drosophila continues to provide new insights into this complex process. Drosophila is highly amenable to study aging because of its short generation time, comprehensive resources for genetic manipulation, and functionally conserved physiology. Importantly, many of these physiological processes such as heart function, sleep, and metabolism functionally senescence in older flies. As the evolutionarily conserved insulin and TOR pathways are critical regulators of aging, the influence of insulin and TOR signaling on these processes is an important area for future research. An important emerging theme is determining the age-dependent alterations that occur at the organ level and how this functional senescence is regulated by different tissues.

KW - Arrhythmia

KW - Cardiac aging

KW - Circadian rhythm

KW - Dietary restriction

KW - Endocrine systems

KW - Heart disease

KW - Heart failure

KW - Insulin

KW - KCNQ

KW - Senescence

KW - Sleep

KW - TOR

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Drosophila aging 2006/2007

Abstract

Keywords

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