Drosophila aging 2006/2007

Paul Shaw, Karen Ocorr, Rolf Bodmer, Sean Oldham

Research output: Contribution to journalShort survey

25 Scopus citations

Abstract

Research on aging in Drosophila continues to provide new insights into this complex process. Drosophila is highly amenable to study aging because of its short generation time, comprehensive resources for genetic manipulation, and functionally conserved physiology. Importantly, many of these physiological processes such as heart function, sleep, and metabolism functionally senescence in older flies. As the evolutionarily conserved insulin and TOR pathways are critical regulators of aging, the influence of insulin and TOR signaling on these processes is an important area for future research. An important emerging theme is determining the age-dependent alterations that occur at the organ level and how this functional senescence is regulated by different tissues.

Original languageEnglish
Pages (from-to)5-10
Number of pages6
JournalExperimental Gerontology
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2008

Keywords

  • Arrhythmia
  • Cardiac aging
  • Circadian rhythm
  • Dietary restriction
  • Endocrine systems
  • Heart disease
  • Heart failure
  • Insulin
  • KCNQ
  • Senescence
  • Sleep
  • TOR

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