Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1

Michael R. Strickland, David M. Holtzman

Research output: Contribution to journalReview article

Abstract

Alzheimer’s disease (AD) is the leading cause of dementia, and its pathogenesis is initiated by the accumulation of amyloid-β (Aβ) into extracellular plaques. Apolipoprotein E4 (ApoE4) is the largest genetic risk factor for sporadic AD and contributes to AD pathogenesis by influencing clearance and seeding of the initial aggregation of Aβ. In this issue of the JCI, Tachibana et al. investigated the relationship between neuronal LRP1 expression and ApoE4-mediated seeding of Aβ and showed that knockout of neuronal LRP1 prevents the increase in Aβ pathology caused by ApoE4 expression. These findings give insight into potential therapeutic targets for the preclinical phase of AD and the pathogenesis of Aβ pathology.

Original languageEnglish
Pages (from-to)969-971
Number of pages3
JournalJournal of Clinical Investigation
Volume129
Issue number3
DOIs
StatePublished - Mar 2019

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