TY - JOUR
T1 - Doxorubicin, vinblastine, and gemcitabine (CALGB 50203) for stage I/II nonbulky Hodgkin lymphoma
T2 - Pretreatment prognostic factors and interim PET
AU - Straus, David J.
AU - Johnson, Jeffrey L.
AU - Lacasce, Ann S.
AU - Bartlett, Nancy L.
AU - Kostakoglu, Lale
AU - Hsi, Eric D.
AU - Schöder, Heiko
AU - Hall, Nathan C.
AU - Jung, Sin Ho
AU - Canellos, George P.
AU - Schwartz, Lawrence H.
AU - Takvorian, Ronald W.
AU - Juweid, Malik E.
AU - Cheson, Bruce D.
PY - 2011/5/19
Y1 - 2011/5/19
N2 - To reduce doxorubicin, bleomycin, vinblastine and dacarbazine toxicity, the Cancer and Leukemia Group B conducted a phase 2 trial of doxorubicin, vinblastine, and gemcitabine for newly diagnosed, nonbulky stages I and II Hodgkin lymphoma. Ninety-nine assessable patients received 6 cycles of doxorubicin 25 mg/m2, vinblastine 6 mg/m2, and gemcitabine 800 mg/m2 (1000 mg/m2 in first 6) on days 1 and 15 every 28 days. Computed tomography (CT) and positron emission tomography (PET) were performed before and after 2 and 6 cycles. Complete remission (CR)/CR unconfirmed was achieved in 72 of 99 patients (72.7%) and partial remission in 24 of 99 patients (24.2%). The CR rate was 81% when using PET criteria. Two patients have died of Hodgkin lymphoma progression. Median follow-up for nonprogressing patients is 3.3 years. The progression-free survival (PFS) at 3 years was 77% (95% confidence interval, 68%-84%). The relapse rate was less than 10% for patients with favorable prognostic factors. The 2-year PFS for cycle 2 PET-negative and-positive patients was 88% and 54%, respectively (P =.0009), compared with 89% and 27% for cycle 6 PET-negative and-positive patients (P =.0001). Although the CR rate and PFS were lower than anticipated, patients with favorable prognostic features had a low rate of relapse. Cycle 2 PET and cycle 6 PET were predictive of PFS. This clinical trial is registered at www.clinicaltrials.gov as #NCT00086801.
AB - To reduce doxorubicin, bleomycin, vinblastine and dacarbazine toxicity, the Cancer and Leukemia Group B conducted a phase 2 trial of doxorubicin, vinblastine, and gemcitabine for newly diagnosed, nonbulky stages I and II Hodgkin lymphoma. Ninety-nine assessable patients received 6 cycles of doxorubicin 25 mg/m2, vinblastine 6 mg/m2, and gemcitabine 800 mg/m2 (1000 mg/m2 in first 6) on days 1 and 15 every 28 days. Computed tomography (CT) and positron emission tomography (PET) were performed before and after 2 and 6 cycles. Complete remission (CR)/CR unconfirmed was achieved in 72 of 99 patients (72.7%) and partial remission in 24 of 99 patients (24.2%). The CR rate was 81% when using PET criteria. Two patients have died of Hodgkin lymphoma progression. Median follow-up for nonprogressing patients is 3.3 years. The progression-free survival (PFS) at 3 years was 77% (95% confidence interval, 68%-84%). The relapse rate was less than 10% for patients with favorable prognostic factors. The 2-year PFS for cycle 2 PET-negative and-positive patients was 88% and 54%, respectively (P =.0009), compared with 89% and 27% for cycle 6 PET-negative and-positive patients (P =.0001). Although the CR rate and PFS were lower than anticipated, patients with favorable prognostic features had a low rate of relapse. Cycle 2 PET and cycle 6 PET were predictive of PFS. This clinical trial is registered at www.clinicaltrials.gov as #NCT00086801.
UR - http://www.scopus.com/inward/record.url?scp=79956356218&partnerID=8YFLogxK
U2 - 10.1182/blood-2010-10-314260
DO - 10.1182/blood-2010-10-314260
M3 - Article
C2 - 21355087
AN - SCOPUS:79956356218
SN - 0006-4971
VL - 117
SP - 5314
EP - 5320
JO - Blood
JF - Blood
IS - 20
ER -