Dosing of renal replacement therapy in acute kidney injury

Anitha Vijayan, Paul M. Palevsky

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

The impact of the intensity of renal replacement therapy on outcomes in patients with acute kidney injury has been studied intensively during the past decade. In this review, we consider the concept of dose of renal replacement therapy in acute kidney injury and summarize the recent clinical trials addressing this topic. Although several single-center trials suggest that more intensive therapy is associated with improved outcomes, 2 large multicenter randomized trials do not find a benefit with higher doses of therapy. Based on these studies, we provide recommendations for the delivered intensity of renal replacement therapy in acute kidney injury.

Original languageEnglish
Pages (from-to)569-576
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume59
Issue number4
DOIs
StatePublished - Apr 2012

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